Setting description

Taxel_therapies less effective in the TP53+ biomarker signature

Simulations setting

PFS distributions


Treatment effects

By subgroup:

subtype var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 4.5, median = 3.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 0.52, hr = 2 af = 1, hr = 1 af = 1, hr = 1
–++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 4.5, median = 3.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 0.52, hr = 2 af = 1, hr = 1 af = 1, hr = 1
-+– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 4.5, median = 3.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 0.52, hr = 2 af = 1, hr = 1 af = 1, hr = 1
-+++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 4.5, median = 3.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 0.52, hr = 2 af = 1, hr = 1 af = 1, hr = 1
+— param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+–+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 4.5, median = 3.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 0.52, hr = 2 af = 1, hr = 1 af = 1, hr = 1
+-++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 4.5, median = 3.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 0.52, hr = 2 af = 1, hr = 1 af = 1, hr = 1
++– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 4.5, median = 3.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 0.52, hr = 2 af = 1, hr = 1 af = 1, hr = 1
++++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 4.5, median = 3.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 0.52, hr = 2 af = 1, hr = 1 af = 1, hr = 1


By signature:

signature var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
all param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.164, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 6, median = 4.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 0.68, hr = 1.5 af = 1, hr = 1 af = 1, hr = 1
TP53- & AR- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
TP53+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.216, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 4.5, median = 3.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 0.52, hr = 2 af = 1, hr = 1 af = 1, hr = 1
DRD+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.164, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 6, median = 4.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 0.68, hr = 1.5 af = 1, hr = 1 af = 1, hr = 1
TEfus+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.164, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 6, median = 4.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 0.68, hr = 1.5 af = 1, hr = 1 af = 1, hr = 1

Errors and power


graduation (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 20 0 2 2
TP53- & AR- 56 31 22 32
TP53+ 34 0 12 29
DRD+ 6 0 8 6
TEfus+ 9 0 3 11
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.040 0.000 0.004 0.004
TP53- & AR- 0.112 0.062 0.044 0.064
TP53+ 0.068 0.000 0.024 0.058
DRD+ 0.012 0.000 0.016 0.012
TEfus+ 0.018 0.000 0.006 0.022
futility (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 3 23 1 0
TP53- & AR- 145 121 109 131
TP53+ 4 366 3 1
DRD+ 9 60 10 5
TEfus+ 3 106 8 5
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.006 0.046 0.002 0.000
TP53- & AR- 0.290 0.242 0.218 0.262
TP53+ 0.008 0.732 0.006 0.002
DRD+ 0.018 0.120 0.020 0.010
TEfus+ 0.006 0.212 0.016 0.010
max sample size (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0 0 0 0
TP53- & AR- 23 12 17 12
TP53+ 23 0 38 28
DRD+ 0 0 0 0
TEfus+ 0 0 1 0
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.000 0.000 0.000 0.000
TP53- & AR- 0.046 0.024 0.034 0.024
TP53+ 0.046 0.000 0.076 0.056
DRD+ 0.000 0.000 0.000 0.000
TEfus+ 0.000 0.000 0.002 0.000


Errors & power

The overall error was 0.44.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.226             0.062             0.082             0.140 

The overall power was .
The corresponding power separate for the different treatments were:

NULL

Median results at the end of the trial

By signature:
signature var Control Hormone_therapies Taxel_therapies Carboplatin Niraparib
all graduation 0 20 0 2 2
futility 0 3 23 1 0
max_n 0 0 0 0 0
n 434 (401, 467) 197 (131, 270) 135 (94, 199) 207 (151, 270) 202 (145, 269)
n_unique 392 (362, 424) 180 (119, 251) 123 (85, 184) 189 (136, 249) 185 (129, 247)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 5 (3, 6) 20 (5, 34) 8 (7, 22) 6 (6, 6)
post_p NA (NA, NA) 0.82 (0.33, 0.99) 0.2 (0.01, 0.74) 0.84 (0.37, 0.99) 0.83 (0.36, 0.99)
rate 0.123 (0.115, 0.132) 0.112 (0.102, 0.126) 0.134 (0.119, 0.164) 0.112 (0.102, 0.124) 0.112 (0.101, 0.125)
TP53- & AR- graduation 0 56 31 22 32
futility 0 145 121 109 131
max_n 0 23 12 17 12
n 178 (153, 204) 64 (25, 133) 65 (26, 124) 73 (29, 128) 66 (26, 125)
n_unique 163 (138, 186) 59 (24, 128) 60 (24, 117) 66 (26, 120) 60 (24, 117)
time_trial 36 (36, 36) 36 (9, 36) 36 (16, 36) 36 (17, 36) 36 (16, 36)
time_stop NA (NA, NA) 12 (7, 27) 20 (12, 31) 20 (13, 31) 21 (11, 31)
post_p NA (NA, NA) 0.49 (0.07, 0.89) 0.44 (0.08, 0.9) 0.48 (0.1, 0.88) 0.5 (0.1, 0.9)
rate 0.113 (0.1, 0.127) 0.114 (0.097, 0.143) 0.115 (0.098, 0.146) 0.114 (0.098, 0.14) 0.114 (0.094, 0.145)
TP53+ graduation 0 34 0 12 29
futility 0 4 366 3 1
max_n 0 23 0 38 28
n 192 (173, 216) 103 (39, 139) 37 (25, 55) 102 (69, 143) 102 (68, 140)
n_unique 173 (154, 196) 94 (35, 128) 33 (23, 51) 92 (61, 131) 93 (61, 130)
time_trial 36 (36, 36) 36 (36, 36) 25 (12, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 10 (8, 19) 20 (11, 32) 12 (9, 30) 13 (8, 32)
post_p NA (NA, NA) 0.93 (0.55, 1) 0.01 (0, 0.06) 0.94 (0.54, 1) 0.93 (0.59, 1)
rate 0.139 (0.124, 0.153) 0.112 (0.097, 0.131) 0.226 (0.186, 0.293) 0.112 (0.098, 0.133) 0.113 (0.096, 0.13)
DRD+ graduation 0 6 0 8 6
futility 0 9 60 10 5
max_n 0 0 0 0 0
n 118 (102, 134) 47 (26, 68) 38 (23, 57) 68 (47, 90) 65 (44, 86)
n_unique 105 (91, 120) 42 (23, 62) 34 (20, 52) 62 (41, 82) 58 (40, 78)
time_trial 36 (36, 36) 36 (36, 36) 36 (34, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 24 (15, 33) 29 (22, 34) 13 (9, 26) 16 (9, 22)
post_p NA (NA, NA) 0.64 (0.19, 0.94) 0.31 (0.04, 0.79) 0.72 (0.26, 0.96) 0.69 (0.23, 0.96)
rate 0.123 (0.107, 0.14) 0.113 (0.093, 0.144) 0.136 (0.107, 0.19) 0.111 (0.095, 0.134) 0.113 (0.095, 0.139)
TEfus+ graduation 0 9 0 3 11
futility 0 3 106 8 5
max_n 0 0 0 1 0
n 159 (138, 177) 73 (40, 100) 52 (29, 74) 80 (55, 107) 78 (49, 108)
n_unique 143 (125, 160) 66 (35, 91) 47 (27, 67) 71 (49, 98) 70 (44, 98)
time_trial 36 (36, 36) 36 (36, 36) 36 (20, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 18 (11, 30) 21 (12, 32) 17 (11, 31) 16 (10, 26)
post_p NA (NA, NA) 0.75 (0.27, 0.98) 0.21 (0.01, 0.71) 0.74 (0.28, 0.97) 0.75 (0.27, 0.98)
rate 0.125 (0.11, 0.141) 0.113 (0.093, 0.134) 0.145 (0.116, 0.187) 0.113 (0.096, 0.134) 0.113 (0.096, 0.135)


By subgroup combinations:
subtype var Control Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- graduation 0 223 164 134 165
futility 0 0 0 0 0
max_n 0 23 12 17 12
n 114 (93, 133) 35 (17, 100) 34 (10, 92) 36 (9, 91) 34 (9, 87)
n_unique 104 (85, 124) 33 (16, 95) 32 (8, 86) 34 (8, 85) 32 (8, 82)
post_p NA (NA, NA) 0.45 (0.1, 0.9) 0.39 (0.1, 0.89) 0.42 (0.08, 0.89) 0.43 (0.1, 0.89)
rate 0.113 (0.097, 0.13) 0.117 (0.094, 0.157) 0.121 (0.094, 0.187) 0.117 (0.093, 0.19) 0.117 (0.093, 0.185)
—+ graduation 0 231 219 139 178
futility 0 0 0 0 0
max_n 0 23 12 18 12
n 22 (15, 29) 7 (2, 20) 8 (3, 21) 7 (2, 20) 7 (2, 19)
n_unique 20 (14, 27) 6 (2, 18) 8 (2, 19) 7 (2, 18) 6 (2, 17)
post_p NA (NA, NA) 0.46 (0.18, 0.83) 0.46 (0.16, 0.83) 0.46 (0.18, 0.85) 0.48 (0.18, 0.86)
rate 0.115 (0.085, 0.157) 0.128 (0.075, 0.31) 0.127 (0.081, 0.319) 0.127 (0.075, 0.325) 0.123 (0.073, 0.328)
–+- graduation 0 60 375 17 32
futility 0 0 0 0 0
max_n 0 23 0 38 28
n 64 (52, 78) 37 (10, 63) 7 (4, 15) 32 (8, 59) 33 (8, 59)
n_unique 57 (46, 72) 34 (10, 59) 7 (3, 14) 29 (7, 55) 30 (7, 54)
post_p NA (NA, NA) 0.78 (0.26, 0.98) 0.16 (0.06, 0.36) 0.76 (0.22, 0.98) 0.74 (0.22, 0.98)
rate 0.14 (0.116, 0.164) 0.116 (0.091, 0.169) 0.252 (0.165, 0.451) 0.116 (0.089, 0.21) 0.117 (0.09, 0.187)
–++ graduation 0 69 399 28 44
futility 0 0 0 0 0
max_n 0 23 0 39 28
n 44 (34, 54) 23 (5, 41) 8 (5, 15) 21 (5, 38) 20 (5, 37)
n_unique 40 (30, 50) 21 (4, 38) 8 (4, 14) 18 (4, 35) 18 (5, 35)
post_p NA (NA, NA) 0.72 (0.24, 0.97) 0.14 (0.04, 0.37) 0.66 (0.21, 0.96) 0.71 (0.24, 0.96)
rate 0.139 (0.113, 0.173) 0.115 (0.087, 0.203) 0.246 (0.169, 0.476) 0.121 (0.085, 0.243) 0.117 (0.085, 0.2)
-+– graduation 0 227 198 149 167
futility 0 0 0 0 0
max_n 0 23 12 17 12
n 21 (15, 28) 5 (0, 16) 7 (2, 19) 11 (3, 23) 9 (3, 19)
n_unique 19 (13, 25) 4 (0, 14) 6 (2, 17) 10 (3, 21) 8 (2, 18)
post_p NA (NA, NA) 0.45 (0.18, 0.81) 0.45 (0.17, 0.84) 0.47 (0.17, 0.86) 0.46 (0.18, 0.8)
rate 0.115 (0.08, 0.157) 0.126 (0.075, 0.384) 0.122 (0.077, 0.336) 0.119 (0.081, 0.251) 0.125 (0.08, 0.278)
-+-+ graduation 0 235 245 153 179
futility 0 0 0 0 0
max_n 0 23 12 18 12
n 21 (15, 28) 5 (0, 18) 6 (2, 18) 10 (3, 23) 9 (3, 21)
n_unique 19 (13, 26) 4 (0, 16) 6 (1, 16) 9 (3, 20) 8 (3, 19)
post_p NA (NA, NA) 0.44 (0.19, 0.83) 0.42 (0.18, 0.84) 0.45 (0.17, 0.83) 0.47 (0.17, 0.87)
rate 0.112 (0.082, 0.161) 0.126 (0.071, 0.319) 0.132 (0.079, 0.32) 0.126 (0.078, 0.234) 0.12 (0.079, 0.26)
-++- graduation 0 75 382 32 42
futility 0 0 0 0 0
max_n 0 23 0 38 28
n 13 (8, 18) 5 (1, 12) 2 (0, 6) 7 (2, 13) 7 (2, 15)
n_unique 11 (7, 16) 4 (1, 11) 2 (0, 5) 6 (2, 12) 6 (2, 14)
post_p NA (NA, NA) 0.55 (0.24, 0.9) 0.32 (0.17, 0.51) 0.59 (0.26, 0.88) 0.6 (0.25, 0.92)
rate 0.141 (0.09, 0.23) 0.125 (0.065, 0.37) 0.29 (0.141, 0.876) 0.128 (0.066, 0.326) 0.123 (0.071, 0.313)
-+++ graduation 0 82 404 41 54
futility 0 0 0 0 0
max_n 0 23 0 39 28
n 13 (8, 18) 5 (1, 11) 2 (1, 5) 7 (2, 14) 7 (2, 15)
n_unique 11 (7, 16) 4 (1, 10) 2 (0, 5) 6 (2, 13) 6 (2, 14)
post_p NA (NA, NA) 0.54 (0.24, 0.87) 0.33 (0.18, 0.5) 0.56 (0.25, 0.91) 0.54 (0.25, 0.88)
rate 0.136 (0.09, 0.225) 0.134 (0.064, 0.375) 0.282 (0.139, 1.075) 0.124 (0.071, 0.36) 0.131 (0.076, 0.3)
+— graduation 0 23 23 3 2
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 20 (15, 28) 8 (2, 19) 11 (4, 21) 8 (3, 18) 8 (3, 18)
n_unique 18 (13, 26) 8 (2, 18) 10 (3, 19) 7 (2, 16) 7 (2, 16)
post_p NA (NA, NA) 0.48 (0.17, 0.86) 0.48 (0.18, 0.86) 0.46 (0.17, 0.83) 0.45 (0.19, 0.83)
rate 0.115 (0.085, 0.162) 0.125 (0.079, 0.315) 0.121 (0.082, 0.259) 0.126 (0.077, 0.348) 0.129 (0.077, 0.319)
+–+ graduation 0 35 115 14 18
futility 0 0 0 0 0
max_n 0 0 0 1 0
n 16 (10, 23) 6 (2, 14) 8 (3, 17) 6 (2, 14) 6 (2, 15)
n_unique 14 (9, 21) 5 (1, 13) 8 (2, 16) 5 (2, 13) 6 (2, 13)
post_p NA (NA, NA) 0.42 (0.18, 0.82) 0.46 (0.18, 0.87) 0.46 (0.21, 0.81) 0.46 (0.19, 0.84)
rate 0.113 (0.08, 0.168) 0.135 (0.074, 0.408) 0.123 (0.074, 0.306) 0.126 (0.074, 0.366) 0.124 (0.071, 0.362)
+-+- graduation 0 60 375 17 32
futility 0 0 0 0 0
max_n 0 23 0 38 28
n 17 (12, 23) 7 (2, 17) 4 (2, 9) 8 (3, 17) 8 (2, 17)
n_unique 15 (10, 21) 6 (1, 15) 4 (2, 9) 7 (2, 16) 7 (2, 16)
post_p NA (NA, NA) 0.56 (0.27, 0.89) 0.26 (0.11, 0.48) 0.59 (0.25, 0.92) 0.61 (0.26, 0.92)
rate 0.139 (0.099, 0.211) 0.127 (0.08, 0.293) 0.258 (0.153, 0.68) 0.125 (0.077, 0.33) 0.118 (0.069, 0.281)
+-++ graduation 0 69 399 28 44
futility 0 0 0 0 0
max_n 0 23 0 39 28
n 17 (11, 23) 7 (2, 16) 4 (2, 8) 8 (2, 17) 8 (2, 17)
n_unique 15 (10, 21) 6 (1, 15) 4 (1, 8) 7 (2, 15) 7 (2, 15)
post_p NA (NA, NA) 0.6 (0.24, 0.92) 0.27 (0.12, 0.49) 0.57 (0.24, 0.93) 0.57 (0.24, 0.92)
rate 0.138 (0.099, 0.208) 0.124 (0.074, 0.353) 0.248 (0.152, 0.716) 0.122 (0.071, 0.376) 0.122 (0.073, 0.308)
++– graduation 0 38 77 21 13
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 12 (7, 17) 4 (1, 10) 5 (2, 10) 6 (2, 13) 6 (2, 12)
n_unique 10 (6, 15) 4 (1, 9) 4 (1, 9) 6 (2, 12) 5 (2, 11)
post_p NA (NA, NA) 0.45 (0.2, 0.8) 0.46 (0.21, 0.82) 0.49 (0.22, 0.83) 0.47 (0.2, 0.84)
rate 0.115 (0.074, 0.18) 0.134 (0.068, 0.461) 0.127 (0.066, 0.419) 0.12 (0.073, 0.326) 0.122 (0.073, 0.371)
++-+ graduation 0 48 153 30 28
futility 0 0 0 0 0
max_n 0 0 0 1 0
n 12 (8, 18) 5 (1, 10) 5 (1, 11) 6 (2, 13) 6 (2, 13)
n_unique 11 (6, 16) 4 (1, 9) 4 (1, 10) 5 (2, 12) 5 (2, 12)
post_p NA (NA, NA) 0.45 (0.21, 0.8) 0.44 (0.22, 0.83) 0.46 (0.19, 0.82) 0.45 (0.18, 0.82)
rate 0.113 (0.076, 0.179) 0.132 (0.064, 0.432) 0.126 (0.065, 0.435) 0.128 (0.068, 0.324) 0.132 (0.072, 0.361)
+++- graduation 0 75 382 32 42
futility 0 0 0 0 0
max_n 0 23 0 38 28
n 12 (8, 18) 4 (1, 11) 2 (1, 6) 7 (2, 15) 7 (2, 14)
n_unique 11 (7, 16) 4 (1, 10) 2 (0, 5) 7 (2, 14) 7 (2, 14)
post_p NA (NA, NA) 0.58 (0.26, 0.89) 0.34 (0.19, 0.5) 0.61 (0.26, 0.92) 0.62 (0.26, 0.91)
rate 0.145 (0.096, 0.233) 0.126 (0.068, 0.354) 0.263 (0.139, 1.024) 0.128 (0.072, 0.351) 0.122 (0.073, 0.344)
++++ graduation 0 82 404 41 54
futility 0 0 0 0 0
max_n 0 23 0 39 28
n 13 (8, 18) 5 (1, 11) 2 (0, 5) 8 (2, 14) 6 (2, 13)
n_unique 11 (7, 16) 4 (1, 10) 2 (0, 5) 7 (2, 13) 5 (2, 12)
post_p NA (NA, NA) 0.54 (0.27, 0.88) 0.32 (0.2, 0.51) 0.57 (0.27, 0.91) 0.56 (0.25, 0.89)
rate 0.141 (0.092, 0.212) 0.125 (0.068, 0.418) 0.274 (0.143, 1.106) 0.123 (0.073, 0.354) 0.127 (0.074, 0.342)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 20 2 2
time_stop 5 (3, 6) 16 (9, 24) 6 (6, 6)
n_trt 32 (26, 46) 106 (54, 159) 26 (25, 26)
n_control 54 (42, 69) 190 (96, 283) 68 (66, 70)
post_p 0.92 (0.87, 0.97) 0.99 (0.98, 0.99) 0.94 (0.92, 0.96)
order 1 (1, 1) 1.5 (1.1, 1.9) 1 (1, 1)
TP53- & AR- count 56 31 22 32
time_stop 10 (7, 20) 13 (9, 24) 15 (12, 31) 15 (10, 26)
n_trt 32 (26, 68) 32 (26, 63) 40 (27, 100) 38 (26, 71)
n_control 48 (30, 87) 60 (43, 108) 69 (49, 153) 64 (43, 121)
post_p 0.91 (0.86, 0.96) 0.92 (0.87, 0.98) 0.94 (0.86, 0.98) 0.95 (0.88, 0.99)
order 1 (1, 2) 1 (1, 2) 1 (1, 2) 1 (1, 2)
TP53+ count 34 12 29
time_stop 10 (8, 20) 12 (9, 27) 13 (8, 32)
n_trt 32 (26, 67) 32 (25, 78) 36 (26, 96)
n_control 46 (33, 93) 54 (37, 128) 67 (35, 157)
post_p 0.97 (0.88, 1) 0.99 (0.96, 1) 0.99 (0.94, 1)
order 1 (1, 2) 1 (1, 1.9) 1 (1, 2.2)
DRD+ count 6 8 6
time_stop 16 (14, 22) 11 (10, 14) 12 (8, 16)
n_trt 26 (25, 37) 26 (26, 33) 28 (25, 36)
n_control 50 (35, 64) 30 (21, 41) 32 (22, 52)
post_p 0.99 (0.97, 1) 0.95 (0.87, 0.98) 0.97 (0.94, 0.98)
order 1 (1, 3) 1 (1, 2) 2 (1, 3)
TEfus+ count 9 3 11
time_stop 16 (12, 31) 11 (10, 13) 12 (10, 17)
n_trt 35 (26, 72) 27 (25, 33) 29 (25, 48)
n_control 56 (37, 152) 42 (39, 49) 46 (29, 63)
post_p 0.99 (0.94, 1) 0.98 (0.94, 1) 0.95 (0.92, 0.99)
order 2 (1, 3) 2 (1.2, 2.8) 1 (1, 1)
Futility:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 3 23 1
time_stop 4 (4, 5) 20 (5, 34) 8 (8, 8)
n_trt 27 (26, 33) 65 (27, 119) 29 (29, 29)
n_control 48 (47, 54) 218 (56, 426) 83 (83, 83)
post_p 0.26 (0.13, 0.28) 0 (0, 0.05) 0.02 (0.02, 0.02)
order 1 (1, 1) 2 (1, 5.8) 1 (1, 1)
TP53- & AR- count 145 121 109 131
time_stop 13 (7, 28) 21 (13, 31) 21 (13, 31) 23 (13, 31)
n_trt 30 (25, 65) 36 (25, 78) 35 (25, 73) 33 (25, 75)
n_control 60 (31, 133) 101 (57, 161) 90 (59, 143) 101 (58, 156)
post_p 0.18 (0.04, 0.28) 0.16 (0.04, 0.26) 0.14 (0.04, 0.27) 0.13 (0.03, 0.27)
order 1 (1, 2) 2 (1, 3) 2 (1, 3.2) 2 (1, 3)
TP53+ count 4 366 3 1
time_stop 11 (9, 12) 20 (11, 32) 17 (15, 28) 20 (20, 20)
n_trt 30 (28, 31) 33 (25, 47) 34 (30, 44) 32 (32, 32)
n_control 50 (36, 63) 100 (48, 169) 80 (76, 147) 101 (101, 101)
post_p 0.19 (0.04, 0.27) 0.01 (0, 0.08) 0.12 (0.08, 0.16) 0.08 (0.08, 0.08)
order 1.5 (1, 2) 1 (1, 3) 2 (1.2, 3.6) 4 (4, 4)
DRD+ count 9 60 10 5
time_stop 30 (23, 34) 29 (22, 34) 16 (8, 28) 21 (17, 28)
n_trt 34 (28, 44) 29 (25, 39) 30 (25, 46) 31 (27, 56)
n_control 100 (69, 115) 85 (59, 115) 46 (17, 74) 64 (46, 99)
post_p 0.05 (0.02, 0.16) 0.06 (0.01, 0.2) 0.07 (0.03, 0.14) 0.01 (0.01, 0.09)
order 3 (2, 4) 3 (2, 4.1) 1.5 (1, 3.1) 4 (2.4, 4)
TEfus+ count 3 106 8 5
time_stop 26 (14, 29) 21 (12, 32) 21 (15, 32) 26 (18, 32)
n_trt 34 (28, 44) 33 (26, 52) 34 (26, 50) 42 (27, 67)
n_control 112 (54, 117) 80 (44, 144) 100 (61, 141) 107 (66, 152)
post_p 0.1 (0.03, 0.22) 0.03 (0, 0.16) 0.06 (0.02, 0.19) 0.08 (0.02, 0.14)
order 2 (1.2, 4.4) 2 (1, 4) 3 (1.7, 4) 2 (1.4, 4.2)


By subgroup combinations

Graduation:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20 20
time 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6) 5 (3, 6)
n 16 (11, 20) 2 (1, 6) 8 (4, 13) 3 (1, 5) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 1 (0, 2) 1 (0, 2) 1 (0, 2) 1 (0, 2) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 1)
post_p 0.7 (0.55, 0.89) 0.6 (0.53, 0.73) 0.7 (0.54, 0.88) 0.64 (0.53, 0.77) 0.52 (0.5, 0.56) 0.54 (0.52, 0.57) 0.54 (0.52, 0.6) 0.54 (0.54, 0.58) 0.55 (0.51, 0.67) 0.55 (0.52, 0.75) 0.59 (0.53, 0.73) 0.6 (0.54, 0.75) 0.52 (0.51, 0.55) 0.53 (0.53, 0.53) 0.59 (0.59, 0.59) 0.52 (0.51, 0.57)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.077 (0.024, 0.103) 0 (0, 0.127) 0.048 (0, 0.099) 0 (0, 0.155) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0.049) 0 (0, 0.204) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
Carboplatin count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
time 16 (9, 24) 16 (9, 24) 16 (9, 24) 16 (9, 24) 16 (9, 24) 16 (9, 24) 16 (9, 24) 16 (9, 24) 16 (9, 24) 16 (9, 24) 16 (9, 24) 16 (9, 24) 16 (9, 24) 16 (9, 24) 16 (9, 24) 16 (9, 24)
n 26 (9, 44) 4 (2, 5) 16 (7, 24) 6 (3, 9) 10 (5, 15) 7 (1, 13) 2 (2, 3) 6 (5, 7) 2 (2, 3) 3 (1, 5) 8 (6, 10) 2 (1, 3) 3 (3, 3) 6 (3, 10) 3 (1, 5) 2 (1, 2)
post_p 0.66 (0.56, 0.76) 0.54 (0.52, 0.56) 0.78 (0.64, 0.92) 0.69 (0.57, 0.82) 0.63 (0.58, 0.68) 0.6 (0.6, 0.6) 0.62 (0.58, 0.65) 0.66 (0.6, 0.72) 0.56 (0.56, 0.57) 0.61 (0.61, 0.61) 0.68 (0.59, 0.77) 0.59 (0.58, 0.6) 0.61 (0.53, 0.69) 0.72 (0.64, 0.79) 0.6 (0.56, 0.64) 0.64 (0.64, 0.65)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.093 (0.09, 0.096) 0.048 (0.01, 0.087) 0.089 (0.088, 0.09) 0.043 (0.009, 0.078) 0.128 (0.101, 0.156) 0.109 (0.109, 0.109) 0.049 (0.01, 0.088) 0.064 (0.051, 0.077) 0.052 (0.01, 0.094) 0.076 (0.076, 0.076) 0.068 (0.014, 0.122) 0.048 (0.01, 0.086) 0.026 (0.005, 0.047) 0.036 (0.007, 0.065) 0.072 (0.014, 0.13) 0.118 (0.114, 0.123)
Niraparib count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
time 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6)
n 2 (2, 3) 1 (0, 2) 4 (4, 5) 2 (1, 4) 2 (1, 2) 3 (3, 3) 1 (0, 2) 2 (1, 2) 0 (0, 0) 2 (1, 2) 0 (0, 1) 2 (1, 2) 0 (0, 1) 2 (0, 3) 0 (0, 1) 2 (2, 2)
post_p 0.6 (0.58, 0.61) 0.58 (0.58, 0.58) 0.64 (0.56, 0.72) 0.59 (0.53, 0.64) 0.61 (0.58, 0.65) 0.7 (0.68, 0.72) 0.58 (0.58, 0.58) 0.51 (0.5, 0.52) NA (NA, NA) 0.55 (0.54, 0.56) 0.57 (0.57, 0.57) 0.54 (0.52, 0.55) 0.63 (0.63, 0.63) 0.51 (0.51, 0.51) 0.62 (0.62, 0.62) 0.56 (0.51, 0.61)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0) 0 (0, 0) 0.041 (0.008, 0.074) 0 (0, 0) 0 (0, 0) 0.039 (0.008, 0.071) 0 (0, 0) 0.086 (0.017, 0.154) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.119 (0.108, 0.13)
TP53- & AR- Hormone_therapies count 56 56 56 56
time 10 (7, 20) 10 (7, 20) 10 (7, 20) 10 (7, 20)
n 26 (20, 48) 4 (2, 8) 1 (0, 5) 2 (0, 6)
post_p 0.8 (0.73, 0.92) 0.69 (0.53, 0.83) 0.6 (0.52, 0.73) 0.6 (0.52, 0.81)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.083 (0.059, 0.107) 0.069 (0, 0.125) 0 (0, 0.094) 0 (0, 0.098)
Taxel_therapies count 31 31 31 31
time 13 (9, 24) 13 (9, 24) 13 (9, 24) 13 (9, 24)
n 24 (17, 45) 5 (2, 16) 3 (0, 5) 3 (1, 8)
post_p 0.8 (0.73, 0.94) 0.72 (0.54, 0.88) 0.66 (0.53, 0.81) 0.61 (0.52, 0.76)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.072 (0.045, 0.1) 0.081 (0, 0.142) 0 (0, 0.104) 0 (0, 0.099)
Carboplatin count 22 22 22 22
time 15 (12, 31) 15 (12, 31) 15 (12, 31) 15 (12, 31)
n 20 (10, 57) 4 (2, 13) 8 (3, 17) 6 (3, 12)
post_p 0.78 (0.72, 0.9) 0.72 (0.51, 0.91) 0.73 (0.57, 0.87) 0.73 (0.56, 0.9)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.088 (0.049, 0.113) 0.065 (0, 0.139) 0.084 (0.054, 0.111) 0.079 (0.033, 0.137)
Niraparib count 32 32 32 32
time 15 (10, 26) 15 (10, 26) 15 (10, 26) 15 (10, 26)
n 20 (12, 40) 4 (1, 6) 6 (4, 11) 6 (4, 10)
post_p 0.79 (0.74, 0.9) 0.64 (0.54, 0.79) 0.77 (0.54, 0.92) 0.73 (0.57, 0.85)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.07 (0.032, 0.097) 0.032 (0, 0.113) 0.055 (0, 0.11) 0.07 (0.026, 0.119)
TP53+ Hormone_therapies count 34 34 34 34 34 34 34 34
time 10 (8, 20) 10 (8, 20) 10 (8, 20) 10 (8, 20) 10 (8, 20) 10 (8, 20) 10 (8, 20) 10 (8, 20)
n 16 (9, 28) 9 (5, 17) 2 (0, 4) 1 (0, 3) 3 (0, 6) 3 (0, 7) 1 (0, 3) 1 (0, 5)
post_p 0.82 (0.72, 0.95) 0.79 (0.65, 0.92) 0.58 (0.51, 0.79) 0.64 (0.55, 0.74) 0.63 (0.56, 0.86) 0.68 (0.54, 0.9) 0.6 (0.57, 0.7) 0.55 (0.5, 0.81)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.088 (0.052, 0.131) 0.084 (0.037, 0.141) 0 (0, 0.144) 0 (0, 0.154) 0.067 (0, 0.122) 0.076 (0, 0.123) 0 (0, 0.156) 0 (0, 0.138)
Carboplatin count 12 12 12 12 12 12 12 12
time 12 (9, 27) 12 (9, 27) 12 (9, 27) 12 (9, 27) 12 (9, 27) 12 (9, 27) 12 (9, 27) 12 (9, 27)
n 10 (4, 38) 6 (2, 17) 3 (1, 6) 2 (0, 6) 4 (1, 11) 3 (1, 5) 4 (1, 5) 2 (0, 5)
post_p 0.82 (0.62, 0.94) 0.79 (0.54, 0.9) 0.72 (0.59, 0.91) 0.64 (0.58, 0.85) 0.74 (0.52, 0.83) 0.6 (0.52, 0.78) 0.71 (0.58, 0.85) 0.72 (0.6, 0.88)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.089 (0.039, 0.114) 0.064 (0, 0.107) 0.033 (0, 0.075) 0.059 (0, 0.148) 0.073 (0, 0.112) 0.069 (0, 0.158) 0.058 (0, 0.147) 0.063 (0, 0.091)
Niraparib count 29 29 29 29 29 29 29 29
time 13 (8, 32) 13 (8, 32) 13 (8, 32) 13 (8, 32) 13 (8, 32) 13 (8, 32) 13 (8, 32) 13 (8, 32)
n 11 (5, 37) 5 (3, 14) 3 (1, 6) 4 (1, 9) 4 (1, 5) 3 (0, 9) 4 (0, 8) 4 (2, 8)
post_p 0.8 (0.58, 0.96) 0.73 (0.56, 0.87) 0.71 (0.56, 0.9) 0.67 (0.51, 0.83) 0.69 (0.53, 0.9) 0.71 (0.59, 0.86) 0.73 (0.54, 0.92) 0.74 (0.55, 0.93)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.085 (0.03, 0.111) 0.081 (0, 0.128) 0.087 (0, 0.171) 0.073 (0, 0.16) 0.051 (0, 0.123) 0.072 (0, 0.147) 0.075 (0, 0.134) 0.067 (0, 0.104)
DRD+ Hormone_therapies count 6 6 6 6 6 6 6 6
time 16 (14, 22) 16 (14, 22) 16 (14, 22) 16 (14, 22) 16 (14, 22) 16 (14, 22) 16 (14, 22) 16 (14, 22)
n 5 (3, 10) 6 (2, 9) 2 (0, 4) 5 (2, 7) 3 (0, 4) 2 (1, 6) 2 (0, 4) 4 (1, 7)
post_p 0.61 (0.55, 0.75) 0.86 (0.65, 0.96) 0.66 (0.58, 0.82) 0.74 (0.61, 0.92) 0.6 (0.58, 0.74) 0.6 (0.56, 0.72) 0.66 (0.55, 0.76) 0.65 (0.53, 0.88)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.07 (0.05, 0.089) 0.046 (0.013, 0.09) 0.041 (0, 0.148) 0.078 (0, 0.137) 0.049 (0, 0.059) 0.063 (0.021, 0.084) 0 (0, 0.138) 0.039 (0, 0.106)
Carboplatin count 8 8 8 8 8 8 8 8
time 11 (10, 14) 11 (10, 14) 11 (10, 14) 11 (10, 14) 11 (10, 14) 11 (10, 14) 11 (10, 14) 11 (10, 14)
n 5 (3, 7) 6 (2, 8) 3 (1, 5) 3 (1, 5) 4 (1, 5) 4 (2, 6) 4 (2, 5) 2 (0, 4)
post_p 0.61 (0.52, 0.78) 0.8 (0.6, 0.95) 0.7 (0.55, 0.79) 0.68 (0.53, 0.75) 0.56 (0.54, 0.75) 0.66 (0.51, 0.82) 0.6 (0.52, 0.82) 0.69 (0.53, 0.89)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.114 (0.037, 0.144) 0.023 (0, 0.108) 0.068 (0, 0.108) 0.107 (0.02, 0.231) 0.018 (0, 0.13) 0.074 (0.041, 0.124) 0.098 (0, 0.204) 0.07 (0, 0.149)
Niraparib count 6 6 6 6 6 6 6 6
time 12 (8, 16) 12 (8, 16) 12 (8, 16) 12 (8, 16) 12 (8, 16) 12 (8, 16) 12 (8, 16) 12 (8, 16)
n 4 (3, 6) 5 (2, 8) 2 (1, 4) 2 (1, 5) 2 (2, 6) 4 (2, 5) 2 (0, 10) 4 (2, 4)
post_p 0.75 (0.55, 0.94) 0.73 (0.6, 0.79) 0.7 (0.56, 0.9) 0.57 (0.52, 0.75) 0.59 (0.53, 0.74) 0.69 (0.54, 0.9) 0.62 (0.51, 0.72) 0.66 (0.55, 0.73)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.046 (0, 0.124) 0.104 (0.033, 0.133) 0.129 (0.034, 0.252) 0.057 (0, 0.206) 0.059 (0, 0.092) 0.088 (0.033, 0.131) 0.095 (0.013, 0.16) 0.069 (0.027, 0.147)
TEfus+ Hormone_therapies count 9 9 9 9 9 9 9 9
time 16 (12, 31) 16 (12, 31) 16 (12, 31) 16 (12, 31) 16 (12, 31) 16 (12, 31) 16 (12, 31) 16 (12, 31)
n 5 (4, 16) 14 (5, 31) 3 (1, 7) 2 (1, 4) 5 (4, 10) 4 (2, 11) 2 (0, 5) 4 (1, 13)
post_p 0.7 (0.56, 0.81) 0.85 (0.67, 0.96) 0.75 (0.51, 0.82) 0.64 (0.57, 0.68) 0.79 (0.53, 0.91) 0.65 (0.54, 0.72) 0.68 (0.56, 0.81) 0.77 (0.6, 0.93)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.089 (0.058, 0.12) 0.089 (0.067, 0.127) 0.045 (0, 0.091) 0.064 (0, 0.15) 0.06 (0.023, 0.119) 0.084 (0, 0.105) 0.028 (0, 0.083) 0.073 (0.024, 0.215)
Carboplatin count 3 3 3 3 3 3 3 3
time 11 (10, 13) 11 (10, 13) 11 (10, 13) 11 (10, 13) 11 (10, 13) 11 (10, 13) 11 (10, 13) 11 (10, 13)
n 6 (4, 7) 4 (3, 6) 3 (3, 6) 3 (1, 4) 1 (0, 3) 3 (1, 4) 4 (1, 7) 3 (3, 4)
post_p 0.76 (0.73, 0.76) 0.62 (0.61, 0.81) 0.7 (0.63, 0.76) 0.52 (0.51, 0.71) 0.59 (0.56, 0.63) 0.71 (0.55, 0.76) 0.79 (0.78, 0.81) 0.58 (0.56, 0.67)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0.028) 0.086 (0.017, 0.089) 0.025 (0.005, 0.047) 0.068 (0.014, 0.303) 0 (0, 0) 0 (0, 0.056) 0.102 (0.068, 0.136) 0.073 (0.015, 0.154)
Niraparib count 11 11 11 11 11 11 11 11
time 12 (10, 17) 12 (10, 17) 12 (10, 17) 12 (10, 17) 12 (10, 17) 12 (10, 17) 12 (10, 17) 12 (10, 17)
n 3 (1, 5) 5 (4, 8) 4 (2, 14) 4 (3, 7) 2 (2, 4) 3 (0, 7) 3 (1, 4) 4 (2, 5)
post_p 0.54 (0.52, 0.7) 0.74 (0.52, 0.88) 0.61 (0.51, 0.74) 0.66 (0.51, 0.86) 0.63 (0.51, 0.7) 0.62 (0.57, 0.85) 0.64 (0.55, 0.87) 0.77 (0.54, 0.84)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.067 (0, 0.183) 0.083 (0.045, 0.16) 0.08 (0, 0.139) 0.106 (0.038, 0.172) 0 (0, 0.16) 0.092 (0, 0.193) 0.027 (0, 0.176) 0.072 (0, 0.095)
Futility:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3
time 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5) 4 (4, 5)
n 13 (9, 15) 1 (0, 4) 8 (7, 12) 3 (1, 4) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 2 (0, 3) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
post_p 0.46 (0.19, 0.48) 0.39 (0.3, 0.47) 0.44 (0.37, 0.48) 0.46 (0.34, 0.49) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.37 (0.37, 0.37) 0.48 (0.48, 0.48) 0.47 (0.47, 0.47) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.055 (0.053, 0.215) 0.058 (0.012, 0.104) 0.214 (0.139, 0.286) 0.137 (0.027, 0.265) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.118 (0.024, 0.212) 0 (0, 0) 0.492 (0.492, 0.492) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA)
Taxel_therapies count 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23 23
time 20 (5, 34) 20 (5, 34) 20 (5, 34) 20 (5, 34) 20 (5, 34) 20 (5, 34) 20 (5, 34) 20 (5, 34) 20 (5, 34) 20 (5, 34) 20 (5, 34) 20 (5, 34) 20 (5, 34) 20 (5, 34) 20 (5, 34) 20 (5, 34)
n 11 (3, 41) 3 (1, 9) 5 (3, 10) 8 (4, 13) 2 (0, 8) 1 (0, 4) 2 (0, 3) 1 (0, 4) 5 (1, 11) 4 (1, 9) 3 (1, 13) 3 (2, 9) 1 (0, 5) 1 (0, 7) 2 (0, 4) 1 (0, 3)
post_p 0.28 (0.09, 0.44) 0.26 (0.16, 0.43) 0.21 (0.08, 0.45) 0.26 (0.04, 0.46) 0.34 (0.23, 0.45) 0.41 (0.18, 0.48) 0.28 (0.21, 0.42) 0.28 (0.08, 0.45) 0.35 (0.21, 0.41) 0.32 (0.15, 0.48) 0.33 (0.08, 0.46) 0.3 (0.16, 0.46) 0.36 (0.23, 0.47) 0.36 (0.26, 0.5) 0.4 (0.29, 0.49) 0.3 (0.21, 0.43)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.142 (0.113, 0.785) 0.258 (0.127, 0.583) 0.271 (0.161, 0.527) 0.216 (0.163, 0.546) 0.163 (0.12, 0.786) 0.168 (0, 0.288) 0.309 (0.194, 0.683) 0.304 (0.173, 0.77) 0.179 (0.117, 0.47) 0.166 (0.102, 0.436) 0.292 (0.153, 1.058) 0.271 (0.106, 0.678) 0.279 (0.133, 1.477) 0.163 (0.103, 0.406) 0.189 (0.089, 0.98) 0.253 (0.106, 1.298)
Carboplatin count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
time 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8)
n 3 (3, 3) 0 (0, 0) 2 (2, 2) 1 (1, 1) 5 (5, 5) 8 (8, 8) 1 (1, 1) 0 (0, 0) 1 (1, 1) 0 (0, 0) 2 (2, 2) 0 (0, 0) 0 (0, 0) 3 (3, 3) 1 (1, 1) 2 (2, 2)
post_p 0.27 (0.27, 0.27) NA (NA, NA) 0.39 (0.39, 0.39) 0.27 (0.27, 0.27) 0.16 (0.16, 0.16) 0.45 (0.45, 0.45) 0.25 (0.25, 0.25) NA (NA, NA) 0.34 (0.34, 0.34) NA (NA, NA) 0.24 (0.24, 0.24) NA (NA, NA) NA (NA, NA) 0.35 (0.35, 0.35) 0.44 (0.44, 0.44) 0.32 (0.32, 0.32)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.322 (0.322, 0.322) NA (NA, NA) 0.206 (0.206, 0.206) 2.238 (2.238, 2.238) 0.074 (0.074, 0.074) 0.201 (0.201, 0.201) 2.036 (2.036, 2.036) NA (NA, NA) 1.442 (1.442, 1.442) NA (NA, NA) 0.2 (0.2, 0.2) NA (NA, NA) NA (NA, NA) 0.294 (0.294, 0.294) 0.249 (0.249, 0.249) 0.369 (0.369, 0.369)
TP53- & AR- Hormone_therapies count 145 145 145 145
time 13 (7, 28) 13 (7, 28) 13 (7, 28) 13 (7, 28)
n 23 (16, 47) 4 (2, 10) 2 (0, 7) 2 (0, 8)
post_p 0.3 (0.11, 0.45) 0.35 (0.16, 0.48) 0.36 (0.23, 0.49) 0.37 (0.22, 0.48)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.13 (0.105, 0.178) 0.173 (0.102, 0.41) 0.194 (0.087, 0.678) 0.196 (0.107, 0.586)
Taxel_therapies count 121 121 121 121
time 21 (13, 31) 21 (13, 31) 21 (13, 31) 21 (13, 31)
n 20 (9, 55) 6 (2, 12) 4 (2, 11) 4 (1, 9)
post_p 0.3 (0.1, 0.46) 0.35 (0.14, 0.48) 0.37 (0.18, 0.48) 0.37 (0.2, 0.48)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.13 (0.109, 0.219) 0.163 (0.097, 0.402) 0.156 (0.101, 0.363) 0.19 (0.107, 0.519)
Carboplatin count 109 109 109 109
time 21 (13, 31) 21 (13, 31) 21 (13, 31) 21 (13, 31)
n 19 (7, 52) 4 (1, 8) 6 (3, 13) 6 (3, 12)
post_p 0.32 (0.11, 0.47) 0.36 (0.16, 0.48) 0.34 (0.15, 0.48) 0.36 (0.16, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.131 (0.105, 0.18) 0.186 (0.103, 0.541) 0.147 (0.096, 0.349) 0.149 (0.095, 0.361)
Niraparib count 131 131 131 131
time 23 (13, 31) 23 (13, 31) 23 (13, 31) 23 (13, 31)
n 16 (7, 55) 4 (2, 11) 7 (3, 13) 6 (2, 13)
post_p 0.3 (0.1, 0.47) 0.36 (0.17, 0.48) 0.34 (0.14, 0.48) 0.34 (0.15, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.134 (0.108, 0.205) 0.169 (0.114, 0.554) 0.142 (0.099, 0.349) 0.156 (0.09, 0.409)
TP53+ Hormone_therapies count 4 4 4 4 4 4 4 4
time 11 (9, 12) 11 (9, 12) 11 (9, 12) 11 (9, 12) 11 (9, 12) 11 (9, 12) 11 (9, 12) 11 (9, 12)
n 16 (15, 17) 4 (3, 4) 1 (0, 3) 1 (0, 2) 1 (0, 4) 2 (2, 3) 2 (1, 2) 2 (0, 4)
post_p 0.36 (0.16, 0.49) 0.3 (0.12, 0.44) 0.5 (0.5, 0.5) 0.35 (0.31, 0.42) 0.44 (0.42, 0.46) 0.4 (0.25, 0.47) 0.32 (0.22, 0.41) 0.27 (0.23, 0.4)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.151 (0.102, 0.179) 0.243 (0.143, 0.379) 0.074 (0.015, 0.133) 0.687 (0.282, 0.838) 0.165 (0.148, 0.182) 0.162 (0.112, 0.307) 0.22 (0.049, 1.008) 0.819 (0.247, 4.35)
Taxel_therapies count 366 366 366 366 366 366 366 366
time 20 (11, 32) 20 (11, 32) 20 (11, 32) 20 (11, 32) 20 (11, 32) 20 (11, 32) 20 (11, 32) 20 (11, 32)
n 7 (4, 14) 8 (5, 15) 2 (0, 5) 2 (0, 5) 4 (2, 8) 4 (2, 8) 2 (0, 5) 2 (0, 5)
post_p 0.2 (0.07, 0.41) 0.17 (0.04, 0.42) 0.34 (0.2, 0.47) 0.35 (0.2, 0.47) 0.29 (0.11, 0.45) 0.28 (0.13, 0.47) 0.35 (0.19, 0.47) 0.34 (0.21, 0.47)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.246 (0.16, 0.45) 0.249 (0.162, 0.49) 0.292 (0.139, 0.991) 0.272 (0.137, 1.198) 0.268 (0.152, 0.723) 0.255 (0.141, 0.729) 0.28 (0.142, 1.205) 0.287 (0.143, 1.245)
Carboplatin count 3 3 3 3 3 3 3 3
time 17 (15, 28) 17 (15, 28) 17 (15, 28) 17 (15, 28) 17 (15, 28) 17 (15, 28) 17 (15, 28) 17 (15, 28)
n 7 (6, 8) 9 (6, 18) 2 (1, 3) 5 (3, 5) 5 (1, 6) 3 (1, 4) 1 (1, 2) 4 (2, 7)
post_p 0.41 (0.37, 0.42) 0.45 (0.31, 0.46) 0.44 (0.37, 0.46) 0.45 (0.32, 0.48) 0.37 (0.33, 0.4) 0.42 (0.37, 0.43) 0.35 (0.29, 0.36) 0.37 (0.32, 0.43)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.158 (0.147, 0.17) 0.18 (0.147, 0.252) 0.137 (0.089, 0.476) 0.197 (0.101, 0.383) 0.129 (0.121, 0.137) 0.2 (0.159, 0.242) 0.493 (0.296, 0.655) 0.201 (0.197, 0.847)
Niraparib count 1 1 1 1 1 1 1 1
time 20 (20, 20) 20 (20, 20) 20 (20, 20) 20 (20, 20) 20 (20, 20) 20 (20, 20) 20 (20, 20) 20 (20, 20)
n 6 (6, 6) 7 (7, 7) 6 (6, 6) 4 (4, 4) 3 (3, 3) 2 (2, 2) 2 (2, 2) 2 (2, 2)
post_p 0.24 (0.24, 0.24) 0.44 (0.44, 0.44) 0.44 (0.44, 0.44) 0.36 (0.36, 0.36) 0.49 (0.49, 0.49) 0.25 (0.25, 0.25) 0.26 (0.26, 0.26) 0.41 (0.41, 0.41)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.176 (0.176, 0.176) 0.188 (0.188, 0.188) 0.11 (0.11, 0.11) 0.202 (0.202, 0.202) 0.136 (0.136, 0.136) 0.291 (0.291, 0.291) 0.348 (0.348, 0.348) 0.19 (0.19, 0.19)
DRD+ Hormone_therapies count 9 9 9 9 9 9 9 9
time 30 (23, 34) 30 (23, 34) 30 (23, 34) 30 (23, 34) 30 (23, 34) 30 (23, 34) 30 (23, 34) 30 (23, 34)
n 2 (0, 5) 4 (0, 10) 6 (2, 14) 3 (2, 6) 4 (1, 6) 5 (3, 8) 3 (2, 10) 3 (1, 6)
post_p 0.36 (0.1, 0.41) 0.37 (0.31, 0.46) 0.42 (0.18, 0.47) 0.42 (0.29, 0.48) 0.42 (0.27, 0.45) 0.41 (0.24, 0.48) 0.36 (0.33, 0.43) 0.35 (0.19, 0.47)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.237 (0.157, 0.553) 0.146 (0.132, 0.306) 0.156 (0.105, 0.316) 0.2 (0.144, 0.29) 0.153 (0.096, 0.51) 0.162 (0.115, 0.266) 0.163 (0.138, 0.286) 0.219 (0.136, 0.302)
Taxel_therapies count 60 60 60 60 60 60 60 60
time 29 (22, 34) 29 (22, 34) 29 (22, 34) 29 (22, 34) 29 (22, 34) 29 (22, 34) 29 (22, 34) 29 (22, 34)
n 5 (2, 13) 5 (2, 11) 2 (1, 6) 2 (1, 5) 4 (1, 7) 4 (1, 8) 2 (1, 5) 2 (0, 5)
post_p 0.34 (0.16, 0.45) 0.35 (0.13, 0.47) 0.34 (0.21, 0.43) 0.32 (0.15, 0.43) 0.36 (0.19, 0.48) 0.36 (0.22, 0.48) 0.35 (0.21, 0.46) 0.34 (0.21, 0.46)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.158 (0.113, 0.413) 0.159 (0.104, 0.348) 0.294 (0.163, 0.786) 0.294 (0.168, 0.885) 0.165 (0.106, 0.573) 0.178 (0.112, 0.664) 0.265 (0.15, 1.697) 0.306 (0.169, 1.229)
Carboplatin count 10 10 10 10 10 10 10 10
time 16 (8, 28) 16 (8, 28) 16 (8, 28) 16 (8, 28) 16 (8, 28) 16 (8, 28) 16 (8, 28) 16 (8, 28)
n 6 (3, 12) 4 (2, 8) 4 (2, 4) 4 (3, 7) 3 (2, 9) 4 (2, 6) 2 (1, 5) 3 (1, 6)
post_p 0.29 (0.17, 0.46) 0.44 (0.36, 0.48) 0.42 (0.2, 0.5) 0.34 (0.23, 0.46) 0.4 (0.18, 0.47) 0.36 (0.14, 0.44) 0.33 (0.28, 0.41) 0.39 (0.24, 0.46)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.17 (0.107, 0.299) 0.149 (0.131, 0.238) 0.208 (0.121, 0.441) 0.202 (0.112, 0.326) 0.167 (0.092, 0.444) 0.219 (0.045, 0.378) 0.584 (0.114, 0.839) 0.191 (0.144, 2.067)
Niraparib count 5 5 5 5 5 5 5 5
time 21 (17, 28) 21 (17, 28) 21 (17, 28) 21 (17, 28) 21 (17, 28) 21 (17, 28) 21 (17, 28) 21 (17, 28)
n 2 (1, 11) 6 (5, 16) 3 (1, 5) 4 (3, 6) 3 (2, 5) 4 (3, 15) 3 (2, 7) 1 (1, 4)
post_p 0.32 (0.12, 0.35) 0.32 (0.18, 0.44) 0.33 (0.17, 0.42) 0.38 (0.14, 0.46) 0.29 (0.21, 0.35) 0.43 (0.24, 0.44) 0.48 (0.28, 0.49) 0.37 (0.28, 0.42)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.294 (0.17, 0.973) 0.122 (0.097, 0.198) 0.238 (0.147, 0.458) 0.249 (0.125, 0.365) 0.211 (0.154, 0.278) 0.139 (0.131, 0.273) 0.196 (0.123, 0.642) 0.335 (0.21, 0.895)
TEfus+ Hormone_therapies count 3 3 3 3 3 3 3 3
time 26 (14, 29) 26 (14, 29) 26 (14, 29) 26 (14, 29) 26 (14, 29) 26 (14, 29) 26 (14, 29) 26 (14, 29)
n 4 (2, 7) 11 (5, 13) 4 (1, 9) 3 (1, 3) 4 (3, 5) 4 (3, 6) 3 (1, 4) 3 (1, 7)
post_p 0.33 (0.29, 0.37) 0.41 (0.28, 0.46) 0.46 (0.45, 0.46) 0.34 (0.23, 0.46) 0.33 (0.29, 0.39) 0.41 (0.38, 0.43) 0.32 (0.27, 0.44) 0.45 (0.29, 0.47)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.222 (0.181, 0.477) 0.142 (0.136, 0.166) 0.127 (0.112, 0.142) 0.377 (0.171, 0.776) 0.128 (0.104, 0.211) 0.135 (0.124, 0.184) 0.239 (0.15, 0.341) 0.24 (0.119, 0.703)
Taxel_therapies count 106 106 106 106 106 106 106 106
time 21 (12, 32) 21 (12, 32) 21 (12, 32) 21 (12, 32) 21 (12, 32) 21 (12, 32) 21 (12, 32) 21 (12, 32)
n 5 (2, 13) 8 (5, 14) 4 (1, 9) 2 (0, 4) 5 (2, 10) 4 (2, 6) 2 (0, 6) 2 (0, 4)
post_p 0.35 (0.14, 0.48) 0.18 (0.03, 0.42) 0.37 (0.2, 0.48) 0.36 (0.2, 0.45) 0.36 (0.18, 0.48) 0.3 (0.14, 0.45) 0.37 (0.21, 0.48) 0.34 (0.21, 0.45)
r_prob 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.165 (0.098, 0.35) 0.233 (0.168, 0.477) 0.167 (0.102, 0.42) 0.304 (0.165, 1.175) 0.157 (0.092, 0.369) 0.233 (0.146, 0.686) 0.217 (0.105, 0.789) 0.293 (0.161, 1.123)
Carboplatin count 8 8 8 8 8 8 8 8
time 21 (15, 32) 21 (15, 32) 21 (15, 32) 21 (15, 32) 21 (15, 32) 21 (15, 32) 21 (15, 32) 21 (15, 32)
n 3 (1, 5) 6 (3, 16) 4 (3, 9) 3 (1, 4) 4 (3, 11) 3 (2, 6) 4 (3, 6) 3 (1, 6)
post_p 0.23 (0.19, 0.36) 0.38 (0.25, 0.49) 0.44 (0.21, 0.49) 0.32 (0.21, 0.44) 0.39 (0.33, 0.47) 0.41 (0.29, 0.47) 0.35 (0.2, 0.46) 0.36 (0.3, 0.44)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.252 (0.162, 1.371) 0.163 (0.119, 0.338) 0.125 (0.082, 0.206) 0.249 (0.183, 0.474) 0.122 (0.098, 0.336) 0.2 (0.149, 0.489) 0.147 (0.127, 0.341) 0.196 (0.132, 0.929)
Niraparib count 5 5 5 5 5 5 5 5
time 26 (18, 32) 26 (18, 32) 26 (18, 32) 26 (18, 32) 26 (18, 32) 26 (18, 32) 26 (18, 32) 26 (18, 32)
n 3 (2, 4) 6 (3, 22) 4 (3, 10) 2 (0, 12) 4 (3, 10) 6 (1, 11) 3 (1, 5) 3 (1, 13)
post_p 0.38 (0.29, 0.43) 0.28 (0.21, 0.38) 0.39 (0.24, 0.44) 0.36 (0.31, 0.41) 0.35 (0.17, 0.38) 0.4 (0.4, 0.42) 0.4 (0.24, 0.49) 0.33 (0.21, 0.45)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.19 (0.122, 0.457) 0.228 (0.151, 0.42) 0.13 (0.128, 0.213) 0.377 (0.152, 0.845) 0.137 (0.111, 0.35) 0.152 (0.124, 0.195) 0.135 (0.122, 0.569) 0.251 (0.157, 0.355)