Simulation scenario 8

Setting description

Taxel_therapies less effective in the TP53+ biomarker signature

Simulations setting

PFS distributions

Treatment effects

By subgroup:

subtype	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
—-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 1, hr = 1	af = 1, hr = 1
–++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 1, hr = 1	af = 1, hr = 1
-+–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 1, hr = 1	af = 1, hr = 1
-+++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 1, hr = 1	af = 1, hr = 1
+—	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+–+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 1, hr = 1	af = 1, hr = 1
+-++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 1, hr = 1	af = 1, hr = 1
++–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 1, hr = 1	af = 1, hr = 1
++++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 1, hr = 1	af = 1, hr = 1

By signature:

signature	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.164, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 6, median = 4.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 0.68, hr = 1.5	af = 1, hr = 1	af = 1, hr = 1
TP53- & AR-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
TP53+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.216, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 4.5, median = 3.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 0.52, hr = 2	af = 1, hr = 1	af = 1, hr = 1
DRD+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.164, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 6, median = 4.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 0.68, hr = 1.5	af = 1, hr = 1	af = 1, hr = 1
TEfus+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.164, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 6, median = 4.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 0.68, hr = 1.5	af = 1, hr = 1	af = 1, hr = 1

Errors and power

graduation (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 20 0 2 2 TP53- & AR- 56 31 22 32 TP53+ 34 0 12 29 DRD+ 6 0 8 6 TEfus+ 9 0 3 11

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.040 0.000 0.004 0.004 TP53- & AR- 0.112 0.062 0.044 0.064 TP53+ 0.068 0.000 0.024 0.058 DRD+ 0.012 0.000 0.016 0.012 TEfus+ 0.018 0.000 0.006 0.022

futility (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 3 23 1 0 TP53- & AR- 145 121 109 131 TP53+ 4 366 3 1 DRD+ 9 60 10 5 TEfus+ 3 106 8 5

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.006 0.046 0.002 0.000 TP53- & AR- 0.290 0.242 0.218 0.262 TP53+ 0.008 0.732 0.006 0.002 DRD+ 0.018 0.120 0.020 0.010 TEfus+ 0.006 0.212 0.016 0.010

max sample size (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0 0 0 0 TP53- & AR- 23 12 17 12 TP53+ 23 0 38 28 DRD+ 0 0 0 0 TEfus+ 0 0 1 0

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.000 0.000 0.000 0.000 TP53- & AR- 0.046 0.024 0.034 0.024 TP53+ 0.046 0.000 0.076 0.056 DRD+ 0.000 0.000 0.000 0.000 TEfus+ 0.000 0.000 0.002 0.000

Errors & power

The overall error was 0.44.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.226             0.062             0.082             0.140 

The overall power was .
The corresponding power separate for the different treatments were:

NULL

Median results at the end of the trial

By signature:

signature	var	Control	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	graduation	0	20	0	2	2
	futility	0	3	23	1	0
	max_n	0	0	0	0	0
	n	434 (401, 467)	197 (131, 270)	135 (94, 199)	207 (151, 270)	202 (145, 269)
	n_unique	392 (362, 424)	180 (119, 251)	123 (85, 184)	189 (136, 249)	185 (129, 247)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	5 (3, 6)	20 (5, 34)	8 (7, 22)	6 (6, 6)
	post_p	NA (NA, NA)	0.82 (0.33, 0.99)	0.2 (0.01, 0.74)	0.84 (0.37, 0.99)	0.83 (0.36, 0.99)
	rate	0.123 (0.115, 0.132)	0.112 (0.102, 0.126)	0.134 (0.119, 0.164)	0.112 (0.102, 0.124)	0.112 (0.101, 0.125)
TP53- & AR-	graduation	0	56	31	22	32
	futility	0	145	121	109	131
	max_n	0	23	12	17	12
	n	178 (153, 204)	64 (25, 133)	65 (26, 124)	73 (29, 128)	66 (26, 125)
	n_unique	163 (138, 186)	59 (24, 128)	60 (24, 117)	66 (26, 120)	60 (24, 117)
	time_trial	36 (36, 36)	36 (9, 36)	36 (16, 36)	36 (17, 36)	36 (16, 36)
	time_stop	NA (NA, NA)	12 (7, 27)	20 (12, 31)	20 (13, 31)	21 (11, 31)
	post_p	NA (NA, NA)	0.49 (0.07, 0.89)	0.44 (0.08, 0.9)	0.48 (0.1, 0.88)	0.5 (0.1, 0.9)
	rate	0.113 (0.1, 0.127)	0.114 (0.097, 0.143)	0.115 (0.098, 0.146)	0.114 (0.098, 0.14)	0.114 (0.094, 0.145)
TP53+	graduation	0	34	0	12	29
	futility	0	4	366	3	1
	max_n	0	23	0	38	28
	n	192 (173, 216)	103 (39, 139)	37 (25, 55)	102 (69, 143)	102 (68, 140)
	n_unique	173 (154, 196)	94 (35, 128)	33 (23, 51)	92 (61, 131)	93 (61, 130)
	time_trial	36 (36, 36)	36 (36, 36)	25 (12, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	10 (8, 19)	20 (11, 32)	12 (9, 30)	13 (8, 32)
	post_p	NA (NA, NA)	0.93 (0.55, 1)	0.01 (0, 0.06)	0.94 (0.54, 1)	0.93 (0.59, 1)
	rate	0.139 (0.124, 0.153)	0.112 (0.097, 0.131)	0.226 (0.186, 0.293)	0.112 (0.098, 0.133)	0.113 (0.096, 0.13)
DRD+	graduation	0	6	0	8	6
	futility	0	9	60	10	5
	max_n	0	0	0	0	0
	n	118 (102, 134)	47 (26, 68)	38 (23, 57)	68 (47, 90)	65 (44, 86)
	n_unique	105 (91, 120)	42 (23, 62)	34 (20, 52)	62 (41, 82)	58 (40, 78)
	time_trial	36 (36, 36)	36 (36, 36)	36 (34, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	24 (15, 33)	29 (22, 34)	13 (9, 26)	16 (9, 22)
	post_p	NA (NA, NA)	0.64 (0.19, 0.94)	0.31 (0.04, 0.79)	0.72 (0.26, 0.96)	0.69 (0.23, 0.96)
	rate	0.123 (0.107, 0.14)	0.113 (0.093, 0.144)	0.136 (0.107, 0.19)	0.111 (0.095, 0.134)	0.113 (0.095, 0.139)
TEfus+	graduation	0	9	0	3	11
	futility	0	3	106	8	5
	max_n	0	0	0	1	0
	n	159 (138, 177)	73 (40, 100)	52 (29, 74)	80 (55, 107)	78 (49, 108)
	n_unique	143 (125, 160)	66 (35, 91)	47 (27, 67)	71 (49, 98)	70 (44, 98)
	time_trial	36 (36, 36)	36 (36, 36)	36 (20, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	18 (11, 30)	21 (12, 32)	17 (11, 31)	16 (10, 26)
	post_p	NA (NA, NA)	0.75 (0.27, 0.98)	0.21 (0.01, 0.71)	0.74 (0.28, 0.97)	0.75 (0.27, 0.98)
	rate	0.125 (0.11, 0.141)	0.113 (0.093, 0.134)	0.145 (0.116, 0.187)	0.113 (0.096, 0.134)	0.113 (0.096, 0.135)

By subgroup combinations:

subtype	var	Control	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
—-	graduation	0	223	164	134	165
	futility	0	0	0	0	0
	max_n	0	23	12	17	12
	n	114 (93, 133)	35 (17, 100)	34 (10, 92)	36 (9, 91)	34 (9, 87)
	n_unique	104 (85, 124)	33 (16, 95)	32 (8, 86)	34 (8, 85)	32 (8, 82)
	post_p	NA (NA, NA)	0.45 (0.1, 0.9)	0.39 (0.1, 0.89)	0.42 (0.08, 0.89)	0.43 (0.1, 0.89)
	rate	0.113 (0.097, 0.13)	0.117 (0.094, 0.157)	0.121 (0.094, 0.187)	0.117 (0.093, 0.19)	0.117 (0.093, 0.185)
—+	graduation	0	231	219	139	178
	futility	0	0	0	0	0
	max_n	0	23	12	18	12
	n	22 (15, 29)	7 (2, 20)	8 (3, 21)	7 (2, 20)	7 (2, 19)
	n_unique	20 (14, 27)	6 (2, 18)	8 (2, 19)	7 (2, 18)	6 (2, 17)
	post_p	NA (NA, NA)	0.46 (0.18, 0.83)	0.46 (0.16, 0.83)	0.46 (0.18, 0.85)	0.48 (0.18, 0.86)
	rate	0.115 (0.085, 0.157)	0.128 (0.075, 0.31)	0.127 (0.081, 0.319)	0.127 (0.075, 0.325)	0.123 (0.073, 0.328)
–+-	graduation	0	60	375	17	32
	futility	0	0	0	0	0
	max_n	0	23	0	38	28
	n	64 (52, 78)	37 (10, 63)	7 (4, 15)	32 (8, 59)	33 (8, 59)
	n_unique	57 (46, 72)	34 (10, 59)	7 (3, 14)	29 (7, 55)	30 (7, 54)
	post_p	NA (NA, NA)	0.78 (0.26, 0.98)	0.16 (0.06, 0.36)	0.76 (0.22, 0.98)	0.74 (0.22, 0.98)
	rate	0.14 (0.116, 0.164)	0.116 (0.091, 0.169)	0.252 (0.165, 0.451)	0.116 (0.089, 0.21)	0.117 (0.09, 0.187)
–++	graduation	0	69	399	28	44
	futility	0	0	0	0	0
	max_n	0	23	0	39	28
	n	44 (34, 54)	23 (5, 41)	8 (5, 15)	21 (5, 38)	20 (5, 37)
	n_unique	40 (30, 50)	21 (4, 38)	8 (4, 14)	18 (4, 35)	18 (5, 35)
	post_p	NA (NA, NA)	0.72 (0.24, 0.97)	0.14 (0.04, 0.37)	0.66 (0.21, 0.96)	0.71 (0.24, 0.96)
	rate	0.139 (0.113, 0.173)	0.115 (0.087, 0.203)	0.246 (0.169, 0.476)	0.121 (0.085, 0.243)	0.117 (0.085, 0.2)
-+–	graduation	0	227	198	149	167
	futility	0	0	0	0	0
	max_n	0	23	12	17	12
	n	21 (15, 28)	5 (0, 16)	7 (2, 19)	11 (3, 23)	9 (3, 19)
	n_unique	19 (13, 25)	4 (0, 14)	6 (2, 17)	10 (3, 21)	8 (2, 18)
	post_p	NA (NA, NA)	0.45 (0.18, 0.81)	0.45 (0.17, 0.84)	0.47 (0.17, 0.86)	0.46 (0.18, 0.8)
	rate	0.115 (0.08, 0.157)	0.126 (0.075, 0.384)	0.122 (0.077, 0.336)	0.119 (0.081, 0.251)	0.125 (0.08, 0.278)
-+-+	graduation	0	235	245	153	179
	futility	0	0	0	0	0
	max_n	0	23	12	18	12
	n	21 (15, 28)	5 (0, 18)	6 (2, 18)	10 (3, 23)	9 (3, 21)
	n_unique	19 (13, 26)	4 (0, 16)	6 (1, 16)	9 (3, 20)	8 (3, 19)
	post_p	NA (NA, NA)	0.44 (0.19, 0.83)	0.42 (0.18, 0.84)	0.45 (0.17, 0.83)	0.47 (0.17, 0.87)
	rate	0.112 (0.082, 0.161)	0.126 (0.071, 0.319)	0.132 (0.079, 0.32)	0.126 (0.078, 0.234)	0.12 (0.079, 0.26)
-++-	graduation	0	75	382	32	42
	futility	0	0	0	0	0
	max_n	0	23	0	38	28
	n	13 (8, 18)	5 (1, 12)	2 (0, 6)	7 (2, 13)	7 (2, 15)
	n_unique	11 (7, 16)	4 (1, 11)	2 (0, 5)	6 (2, 12)	6 (2, 14)
	post_p	NA (NA, NA)	0.55 (0.24, 0.9)	0.32 (0.17, 0.51)	0.59 (0.26, 0.88)	0.6 (0.25, 0.92)
	rate	0.141 (0.09, 0.23)	0.125 (0.065, 0.37)	0.29 (0.141, 0.876)	0.128 (0.066, 0.326)	0.123 (0.071, 0.313)
-+++	graduation	0	82	404	41	54
	futility	0	0	0	0	0
	max_n	0	23	0	39	28
	n	13 (8, 18)	5 (1, 11)	2 (1, 5)	7 (2, 14)	7 (2, 15)
	n_unique	11 (7, 16)	4 (1, 10)	2 (0, 5)	6 (2, 13)	6 (2, 14)
	post_p	NA (NA, NA)	0.54 (0.24, 0.87)	0.33 (0.18, 0.5)	0.56 (0.25, 0.91)	0.54 (0.25, 0.88)
	rate	0.136 (0.09, 0.225)	0.134 (0.064, 0.375)	0.282 (0.139, 1.075)	0.124 (0.071, 0.36)	0.131 (0.076, 0.3)
+—	graduation	0	23	23	3	2
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	20 (15, 28)	8 (2, 19)	11 (4, 21)	8 (3, 18)	8 (3, 18)
	n_unique	18 (13, 26)	8 (2, 18)	10 (3, 19)	7 (2, 16)	7 (2, 16)
	post_p	NA (NA, NA)	0.48 (0.17, 0.86)	0.48 (0.18, 0.86)	0.46 (0.17, 0.83)	0.45 (0.19, 0.83)
	rate	0.115 (0.085, 0.162)	0.125 (0.079, 0.315)	0.121 (0.082, 0.259)	0.126 (0.077, 0.348)	0.129 (0.077, 0.319)
+–+	graduation	0	35	115	14	18
	futility	0	0	0	0	0
	max_n	0	0	0	1	0
	n	16 (10, 23)	6 (2, 14)	8 (3, 17)	6 (2, 14)	6 (2, 15)
	n_unique	14 (9, 21)	5 (1, 13)	8 (2, 16)	5 (2, 13)	6 (2, 13)
	post_p	NA (NA, NA)	0.42 (0.18, 0.82)	0.46 (0.18, 0.87)	0.46 (0.21, 0.81)	0.46 (0.19, 0.84)
	rate	0.113 (0.08, 0.168)	0.135 (0.074, 0.408)	0.123 (0.074, 0.306)	0.126 (0.074, 0.366)	0.124 (0.071, 0.362)
+-+-	graduation	0	60	375	17	32
	futility	0	0	0	0	0
	max_n	0	23	0	38	28
	n	17 (12, 23)	7 (2, 17)	4 (2, 9)	8 (3, 17)	8 (2, 17)
	n_unique	15 (10, 21)	6 (1, 15)	4 (2, 9)	7 (2, 16)	7 (2, 16)
	post_p	NA (NA, NA)	0.56 (0.27, 0.89)	0.26 (0.11, 0.48)	0.59 (0.25, 0.92)	0.61 (0.26, 0.92)
	rate	0.139 (0.099, 0.211)	0.127 (0.08, 0.293)	0.258 (0.153, 0.68)	0.125 (0.077, 0.33)	0.118 (0.069, 0.281)
+-++	graduation	0	69	399	28	44
	futility	0	0	0	0	0
	max_n	0	23	0	39	28
	n	17 (11, 23)	7 (2, 16)	4 (2, 8)	8 (2, 17)	8 (2, 17)
	n_unique	15 (10, 21)	6 (1, 15)	4 (1, 8)	7 (2, 15)	7 (2, 15)
	post_p	NA (NA, NA)	0.6 (0.24, 0.92)	0.27 (0.12, 0.49)	0.57 (0.24, 0.93)	0.57 (0.24, 0.92)
	rate	0.138 (0.099, 0.208)	0.124 (0.074, 0.353)	0.248 (0.152, 0.716)	0.122 (0.071, 0.376)	0.122 (0.073, 0.308)
++–	graduation	0	38	77	21	13
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	12 (7, 17)	4 (1, 10)	5 (2, 10)	6 (2, 13)	6 (2, 12)
	n_unique	10 (6, 15)	4 (1, 9)	4 (1, 9)	6 (2, 12)	5 (2, 11)
	post_p	NA (NA, NA)	0.45 (0.2, 0.8)	0.46 (0.21, 0.82)	0.49 (0.22, 0.83)	0.47 (0.2, 0.84)
	rate	0.115 (0.074, 0.18)	0.134 (0.068, 0.461)	0.127 (0.066, 0.419)	0.12 (0.073, 0.326)	0.122 (0.073, 0.371)
++-+	graduation	0	48	153	30	28
	futility	0	0	0	0	0
	max_n	0	0	0	1	0
	n	12 (8, 18)	5 (1, 10)	5 (1, 11)	6 (2, 13)	6 (2, 13)
	n_unique	11 (6, 16)	4 (1, 9)	4 (1, 10)	5 (2, 12)	5 (2, 12)
	post_p	NA (NA, NA)	0.45 (0.21, 0.8)	0.44 (0.22, 0.83)	0.46 (0.19, 0.82)	0.45 (0.18, 0.82)
	rate	0.113 (0.076, 0.179)	0.132 (0.064, 0.432)	0.126 (0.065, 0.435)	0.128 (0.068, 0.324)	0.132 (0.072, 0.361)
+++-	graduation	0	75	382	32	42
	futility	0	0	0	0	0
	max_n	0	23	0	38	28
	n	12 (8, 18)	4 (1, 11)	2 (1, 6)	7 (2, 15)	7 (2, 14)
	n_unique	11 (7, 16)	4 (1, 10)	2 (0, 5)	7 (2, 14)	7 (2, 14)
	post_p	NA (NA, NA)	0.58 (0.26, 0.89)	0.34 (0.19, 0.5)	0.61 (0.26, 0.92)	0.62 (0.26, 0.91)
	rate	0.145 (0.096, 0.233)	0.126 (0.068, 0.354)	0.263 (0.139, 1.024)	0.128 (0.072, 0.351)	0.122 (0.073, 0.344)
++++	graduation	0	82	404	41	54
	futility	0	0	0	0	0
	max_n	0	23	0	39	28
	n	13 (8, 18)	5 (1, 11)	2 (0, 5)	8 (2, 14)	6 (2, 13)
	n_unique	11 (7, 16)	4 (1, 10)	2 (0, 5)	7 (2, 13)	5 (2, 12)
	post_p	NA (NA, NA)	0.54 (0.27, 0.88)	0.32 (0.2, 0.51)	0.57 (0.27, 0.91)	0.56 (0.25, 0.89)
	rate	0.141 (0.092, 0.212)	0.125 (0.068, 0.418)	0.274 (0.143, 1.106)	0.123 (0.073, 0.354)	0.127 (0.074, 0.342)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	count	20		2	2
	time_stop	5 (3, 6)		16 (9, 24)	6 (6, 6)
	n_trt	32 (26, 46)		106 (54, 159)	26 (25, 26)
	n_control	54 (42, 69)		190 (96, 283)	68 (66, 70)
	post_p	0.92 (0.87, 0.97)		0.99 (0.98, 0.99)	0.94 (0.92, 0.96)
	order	1 (1, 1)		1.5 (1.1, 1.9)	1 (1, 1)
TP53- & AR-	count	56	31	22	32
	time_stop	10 (7, 20)	13 (9, 24)	15 (12, 31)	15 (10, 26)
	n_trt	32 (26, 68)	32 (26, 63)	40 (27, 100)	38 (26, 71)
	n_control	48 (30, 87)	60 (43, 108)	69 (49, 153)	64 (43, 121)
	post_p	0.91 (0.86, 0.96)	0.92 (0.87, 0.98)	0.94 (0.86, 0.98)	0.95 (0.88, 0.99)
	order	1 (1, 2)	1 (1, 2)	1 (1, 2)	1 (1, 2)
TP53+	count	34		12	29
	time_stop	10 (8, 20)		12 (9, 27)	13 (8, 32)
	n_trt	32 (26, 67)		32 (25, 78)	36 (26, 96)
	n_control	46 (33, 93)		54 (37, 128)	67 (35, 157)
	post_p	0.97 (0.88, 1)		0.99 (0.96, 1)	0.99 (0.94, 1)
	order	1 (1, 2)		1 (1, 1.9)	1 (1, 2.2)
DRD+	count	6		8	6
	time_stop	16 (14, 22)		11 (10, 14)	12 (8, 16)
	n_trt	26 (25, 37)		26 (26, 33)	28 (25, 36)
	n_control	50 (35, 64)		30 (21, 41)	32 (22, 52)
	post_p	0.99 (0.97, 1)		0.95 (0.87, 0.98)	0.97 (0.94, 0.98)
	order	1 (1, 3)		1 (1, 2)	2 (1, 3)
TEfus+	count	9		3	11
	time_stop	16 (12, 31)		11 (10, 13)	12 (10, 17)
	n_trt	35 (26, 72)		27 (25, 33)	29 (25, 48)
	n_control	56 (37, 152)		42 (39, 49)	46 (29, 63)
	post_p	0.99 (0.94, 1)		0.98 (0.94, 1)	0.95 (0.92, 0.99)
	order	2 (1, 3)		2 (1.2, 2.8)	1 (1, 1)

Futility:

signature	var	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	count	3	23	1
	time_stop	4 (4, 5)	20 (5, 34)	8 (8, 8)
	n_trt	27 (26, 33)	65 (27, 119)	29 (29, 29)
	n_control	48 (47, 54)	218 (56, 426)	83 (83, 83)
	post_p	0.26 (0.13, 0.28)	0 (0, 0.05)	0.02 (0.02, 0.02)
	order	1 (1, 1)	2 (1, 5.8)	1 (1, 1)
TP53- & AR-	count	145	121	109	131
	time_stop	13 (7, 28)	21 (13, 31)	21 (13, 31)	23 (13, 31)
	n_trt	30 (25, 65)	36 (25, 78)	35 (25, 73)	33 (25, 75)
	n_control	60 (31, 133)	101 (57, 161)	90 (59, 143)	101 (58, 156)
	post_p	0.18 (0.04, 0.28)	0.16 (0.04, 0.26)	0.14 (0.04, 0.27)	0.13 (0.03, 0.27)
	order	1 (1, 2)	2 (1, 3)	2 (1, 3.2)	2 (1, 3)
TP53+	count	4	366	3	1
	time_stop	11 (9, 12)	20 (11, 32)	17 (15, 28)	20 (20, 20)
	n_trt	30 (28, 31)	33 (25, 47)	34 (30, 44)	32 (32, 32)
	n_control	50 (36, 63)	100 (48, 169)	80 (76, 147)	101 (101, 101)
	post_p	0.19 (0.04, 0.27)	0.01 (0, 0.08)	0.12 (0.08, 0.16)	0.08 (0.08, 0.08)
	order	1.5 (1, 2)	1 (1, 3)	2 (1.2, 3.6)	4 (4, 4)
DRD+	count	9	60	10	5
	time_stop	30 (23, 34)	29 (22, 34)	16 (8, 28)	21 (17, 28)
	n_trt	34 (28, 44)	29 (25, 39)	30 (25, 46)	31 (27, 56)
	n_control	100 (69, 115)	85 (59, 115)	46 (17, 74)	64 (46, 99)
	post_p	0.05 (0.02, 0.16)	0.06 (0.01, 0.2)	0.07 (0.03, 0.14)	0.01 (0.01, 0.09)
	order	3 (2, 4)	3 (2, 4.1)	1.5 (1, 3.1)	4 (2.4, 4)
TEfus+	count	3	106	8	5
	time_stop	26 (14, 29)	21 (12, 32)	21 (15, 32)	26 (18, 32)
	n_trt	34 (28, 44)	33 (26, 52)	34 (26, 50)	42 (27, 67)
	n_control	112 (54, 117)	80 (44, 144)	100 (61, 141)	107 (66, 152)
	post_p	0.1 (0.03, 0.22)	0.03 (0, 0.16)	0.06 (0.02, 0.19)	0.08 (0.02, 0.14)
	order	2 (1.2, 4.4)	2 (1, 4)	3 (1.7, 4)	2 (1.4, 4.2)

By subgroup combinations

Graduation:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Hormone_therapies	count	20	20	20	20	20	20	20	20	20	20	20	20	20	20	20	20
		time	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)	5 (3, 6)
		n	16 (11, 20)	2 (1, 6)	8 (4, 13)	3 (1, 5)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	1 (0, 2)	1 (0, 2)	1 (0, 2)	1 (0, 2)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 1)
		post_p	0.7 (0.55, 0.89)	0.6 (0.53, 0.73)	0.7 (0.54, 0.88)	0.64 (0.53, 0.77)	0.52 (0.5, 0.56)	0.54 (0.52, 0.57)	0.54 (0.52, 0.6)	0.54 (0.54, 0.58)	0.55 (0.51, 0.67)	0.55 (0.52, 0.75)	0.59 (0.53, 0.73)	0.6 (0.54, 0.75)	0.52 (0.51, 0.55)	0.53 (0.53, 0.53)	0.59 (0.59, 0.59)	0.52 (0.51, 0.57)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.077 (0.024, 0.103)	0 (0, 0.127)	0.048 (0, 0.099)	0 (0, 0.155)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0.049)	0 (0, 0.204)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
	Carboplatin	count	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
		time	16 (9, 24)	16 (9, 24)	16 (9, 24)	16 (9, 24)	16 (9, 24)	16 (9, 24)	16 (9, 24)	16 (9, 24)	16 (9, 24)	16 (9, 24)	16 (9, 24)	16 (9, 24)	16 (9, 24)	16 (9, 24)	16 (9, 24)	16 (9, 24)
		n	26 (9, 44)	4 (2, 5)	16 (7, 24)	6 (3, 9)	10 (5, 15)	7 (1, 13)	2 (2, 3)	6 (5, 7)	2 (2, 3)	3 (1, 5)	8 (6, 10)	2 (1, 3)	3 (3, 3)	6 (3, 10)	3 (1, 5)	2 (1, 2)
		post_p	0.66 (0.56, 0.76)	0.54 (0.52, 0.56)	0.78 (0.64, 0.92)	0.69 (0.57, 0.82)	0.63 (0.58, 0.68)	0.6 (0.6, 0.6)	0.62 (0.58, 0.65)	0.66 (0.6, 0.72)	0.56 (0.56, 0.57)	0.61 (0.61, 0.61)	0.68 (0.59, 0.77)	0.59 (0.58, 0.6)	0.61 (0.53, 0.69)	0.72 (0.64, 0.79)	0.6 (0.56, 0.64)	0.64 (0.64, 0.65)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.093 (0.09, 0.096)	0.048 (0.01, 0.087)	0.089 (0.088, 0.09)	0.043 (0.009, 0.078)	0.128 (0.101, 0.156)	0.109 (0.109, 0.109)	0.049 (0.01, 0.088)	0.064 (0.051, 0.077)	0.052 (0.01, 0.094)	0.076 (0.076, 0.076)	0.068 (0.014, 0.122)	0.048 (0.01, 0.086)	0.026 (0.005, 0.047)	0.036 (0.007, 0.065)	0.072 (0.014, 0.13)	0.118 (0.114, 0.123)
	Niraparib	count	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
		time	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)
		n	2 (2, 3)	1 (0, 2)	4 (4, 5)	2 (1, 4)	2 (1, 2)	3 (3, 3)	1 (0, 2)	2 (1, 2)	0 (0, 0)	2 (1, 2)	0 (0, 1)	2 (1, 2)	0 (0, 1)	2 (0, 3)	0 (0, 1)	2 (2, 2)
		post_p	0.6 (0.58, 0.61)	0.58 (0.58, 0.58)	0.64 (0.56, 0.72)	0.59 (0.53, 0.64)	0.61 (0.58, 0.65)	0.7 (0.68, 0.72)	0.58 (0.58, 0.58)	0.51 (0.5, 0.52)	NA (NA, NA)	0.55 (0.54, 0.56)	0.57 (0.57, 0.57)	0.54 (0.52, 0.55)	0.63 (0.63, 0.63)	0.51 (0.51, 0.51)	0.62 (0.62, 0.62)	0.56 (0.51, 0.61)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0 (0, 0)	0 (0, 0)	0.041 (0.008, 0.074)	0 (0, 0)	0 (0, 0)	0.039 (0.008, 0.071)	0 (0, 0)	0.086 (0.017, 0.154)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.119 (0.108, 0.13)
TP53- & AR-	Hormone_therapies	count	56	56			56	56
		time	10 (7, 20)	10 (7, 20)			10 (7, 20)	10 (7, 20)
		n	26 (20, 48)	4 (2, 8)			1 (0, 5)	2 (0, 6)
		post_p	0.8 (0.73, 0.92)	0.69 (0.53, 0.83)			0.6 (0.52, 0.73)	0.6 (0.52, 0.81)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.083 (0.059, 0.107)	0.069 (0, 0.125)			0 (0, 0.094)	0 (0, 0.098)
	Taxel_therapies	count	31	31			31	31
		time	13 (9, 24)	13 (9, 24)			13 (9, 24)	13 (9, 24)
		n	24 (17, 45)	5 (2, 16)			3 (0, 5)	3 (1, 8)
		post_p	0.8 (0.73, 0.94)	0.72 (0.54, 0.88)			0.66 (0.53, 0.81)	0.61 (0.52, 0.76)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.072 (0.045, 0.1)	0.081 (0, 0.142)			0 (0, 0.104)	0 (0, 0.099)
	Carboplatin	count	22	22			22	22
		time	15 (12, 31)	15 (12, 31)			15 (12, 31)	15 (12, 31)
		n	20 (10, 57)	4 (2, 13)			8 (3, 17)	6 (3, 12)
		post_p	0.78 (0.72, 0.9)	0.72 (0.51, 0.91)			0.73 (0.57, 0.87)	0.73 (0.56, 0.9)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.088 (0.049, 0.113)	0.065 (0, 0.139)			0.084 (0.054, 0.111)	0.079 (0.033, 0.137)
	Niraparib	count	32	32			32	32
		time	15 (10, 26)	15 (10, 26)			15 (10, 26)	15 (10, 26)
		n	20 (12, 40)	4 (1, 6)			6 (4, 11)	6 (4, 10)
		post_p	0.79 (0.74, 0.9)	0.64 (0.54, 0.79)			0.77 (0.54, 0.92)	0.73 (0.57, 0.85)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.07 (0.032, 0.097)	0.032 (0, 0.113)			0.055 (0, 0.11)	0.07 (0.026, 0.119)
TP53+	Hormone_therapies	count			34	34			34	34			34	34			34	34
		time			10 (8, 20)	10 (8, 20)			10 (8, 20)	10 (8, 20)			10 (8, 20)	10 (8, 20)			10 (8, 20)	10 (8, 20)
		n			16 (9, 28)	9 (5, 17)			2 (0, 4)	1 (0, 3)			3 (0, 6)	3 (0, 7)			1 (0, 3)	1 (0, 5)
		post_p			0.82 (0.72, 0.95)	0.79 (0.65, 0.92)			0.58 (0.51, 0.79)	0.64 (0.55, 0.74)			0.63 (0.56, 0.86)	0.68 (0.54, 0.9)			0.6 (0.57, 0.7)	0.55 (0.5, 0.81)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.088 (0.052, 0.131)	0.084 (0.037, 0.141)			0 (0, 0.144)	0 (0, 0.154)			0.067 (0, 0.122)	0.076 (0, 0.123)			0 (0, 0.156)	0 (0, 0.138)
	Carboplatin	count			12	12			12	12			12	12			12	12
		time			12 (9, 27)	12 (9, 27)			12 (9, 27)	12 (9, 27)			12 (9, 27)	12 (9, 27)			12 (9, 27)	12 (9, 27)
		n			10 (4, 38)	6 (2, 17)			3 (1, 6)	2 (0, 6)			4 (1, 11)	3 (1, 5)			4 (1, 5)	2 (0, 5)
		post_p			0.82 (0.62, 0.94)	0.79 (0.54, 0.9)			0.72 (0.59, 0.91)	0.64 (0.58, 0.85)			0.74 (0.52, 0.83)	0.6 (0.52, 0.78)			0.71 (0.58, 0.85)	0.72 (0.6, 0.88)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.089 (0.039, 0.114)	0.064 (0, 0.107)			0.033 (0, 0.075)	0.059 (0, 0.148)			0.073 (0, 0.112)	0.069 (0, 0.158)			0.058 (0, 0.147)	0.063 (0, 0.091)
	Niraparib	count			29	29			29	29			29	29			29	29
		time			13 (8, 32)	13 (8, 32)			13 (8, 32)	13 (8, 32)			13 (8, 32)	13 (8, 32)			13 (8, 32)	13 (8, 32)
		n			11 (5, 37)	5 (3, 14)			3 (1, 6)	4 (1, 9)			4 (1, 5)	3 (0, 9)			4 (0, 8)	4 (2, 8)
		post_p			0.8 (0.58, 0.96)	0.73 (0.56, 0.87)			0.71 (0.56, 0.9)	0.67 (0.51, 0.83)			0.69 (0.53, 0.9)	0.71 (0.59, 0.86)			0.73 (0.54, 0.92)	0.74 (0.55, 0.93)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.085 (0.03, 0.111)	0.081 (0, 0.128)			0.087 (0, 0.171)	0.073 (0, 0.16)			0.051 (0, 0.123)	0.072 (0, 0.147)			0.075 (0, 0.134)	0.067 (0, 0.104)
DRD+	Hormone_therapies	count					6	6	6	6					6	6	6	6
		time					16 (14, 22)	16 (14, 22)	16 (14, 22)	16 (14, 22)					16 (14, 22)	16 (14, 22)	16 (14, 22)	16 (14, 22)
		n					5 (3, 10)	6 (2, 9)	2 (0, 4)	5 (2, 7)					3 (0, 4)	2 (1, 6)	2 (0, 4)	4 (1, 7)
		post_p					0.61 (0.55, 0.75)	0.86 (0.65, 0.96)	0.66 (0.58, 0.82)	0.74 (0.61, 0.92)					0.6 (0.58, 0.74)	0.6 (0.56, 0.72)	0.66 (0.55, 0.76)	0.65 (0.53, 0.88)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.07 (0.05, 0.089)	0.046 (0.013, 0.09)	0.041 (0, 0.148)	0.078 (0, 0.137)					0.049 (0, 0.059)	0.063 (0.021, 0.084)	0 (0, 0.138)	0.039 (0, 0.106)
	Carboplatin	count					8	8	8	8					8	8	8	8
		time					11 (10, 14)	11 (10, 14)	11 (10, 14)	11 (10, 14)					11 (10, 14)	11 (10, 14)	11 (10, 14)	11 (10, 14)
		n					5 (3, 7)	6 (2, 8)	3 (1, 5)	3 (1, 5)					4 (1, 5)	4 (2, 6)	4 (2, 5)	2 (0, 4)
		post_p					0.61 (0.52, 0.78)	0.8 (0.6, 0.95)	0.7 (0.55, 0.79)	0.68 (0.53, 0.75)					0.56 (0.54, 0.75)	0.66 (0.51, 0.82)	0.6 (0.52, 0.82)	0.69 (0.53, 0.89)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.114 (0.037, 0.144)	0.023 (0, 0.108)	0.068 (0, 0.108)	0.107 (0.02, 0.231)					0.018 (0, 0.13)	0.074 (0.041, 0.124)	0.098 (0, 0.204)	0.07 (0, 0.149)
	Niraparib	count					6	6	6	6					6	6	6	6
		time					12 (8, 16)	12 (8, 16)	12 (8, 16)	12 (8, 16)					12 (8, 16)	12 (8, 16)	12 (8, 16)	12 (8, 16)
		n					4 (3, 6)	5 (2, 8)	2 (1, 4)	2 (1, 5)					2 (2, 6)	4 (2, 5)	2 (0, 10)	4 (2, 4)
		post_p					0.75 (0.55, 0.94)	0.73 (0.6, 0.79)	0.7 (0.56, 0.9)	0.57 (0.52, 0.75)					0.59 (0.53, 0.74)	0.69 (0.54, 0.9)	0.62 (0.51, 0.72)	0.66 (0.55, 0.73)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.046 (0, 0.124)	0.104 (0.033, 0.133)	0.129 (0.034, 0.252)	0.057 (0, 0.206)					0.059 (0, 0.092)	0.088 (0.033, 0.131)	0.095 (0.013, 0.16)	0.069 (0.027, 0.147)
TEfus+	Hormone_therapies	count		9		9		9		9		9		9		9		9
		time		16 (12, 31)		16 (12, 31)		16 (12, 31)		16 (12, 31)		16 (12, 31)		16 (12, 31)		16 (12, 31)		16 (12, 31)
		n		5 (4, 16)		14 (5, 31)		3 (1, 7)		2 (1, 4)		5 (4, 10)		4 (2, 11)		2 (0, 5)		4 (1, 13)
		post_p		0.7 (0.56, 0.81)		0.85 (0.67, 0.96)		0.75 (0.51, 0.82)		0.64 (0.57, 0.68)		0.79 (0.53, 0.91)		0.65 (0.54, 0.72)		0.68 (0.56, 0.81)		0.77 (0.6, 0.93)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.089 (0.058, 0.12)		0.089 (0.067, 0.127)		0.045 (0, 0.091)		0.064 (0, 0.15)		0.06 (0.023, 0.119)		0.084 (0, 0.105)		0.028 (0, 0.083)		0.073 (0.024, 0.215)
	Carboplatin	count		3		3		3		3		3		3		3		3
		time		11 (10, 13)		11 (10, 13)		11 (10, 13)		11 (10, 13)		11 (10, 13)		11 (10, 13)		11 (10, 13)		11 (10, 13)
		n		6 (4, 7)		4 (3, 6)		3 (3, 6)		3 (1, 4)		1 (0, 3)		3 (1, 4)		4 (1, 7)		3 (3, 4)
		post_p		0.76 (0.73, 0.76)		0.62 (0.61, 0.81)		0.7 (0.63, 0.76)		0.52 (0.51, 0.71)		0.59 (0.56, 0.63)		0.71 (0.55, 0.76)		0.79 (0.78, 0.81)		0.58 (0.56, 0.67)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0 (0, 0.028)		0.086 (0.017, 0.089)		0.025 (0.005, 0.047)		0.068 (0.014, 0.303)		0 (0, 0)		0 (0, 0.056)		0.102 (0.068, 0.136)		0.073 (0.015, 0.154)
	Niraparib	count		11		11		11		11		11		11		11		11
		time		12 (10, 17)		12 (10, 17)		12 (10, 17)		12 (10, 17)		12 (10, 17)		12 (10, 17)		12 (10, 17)		12 (10, 17)
		n		3 (1, 5)		5 (4, 8)		4 (2, 14)		4 (3, 7)		2 (2, 4)		3 (0, 7)		3 (1, 4)		4 (2, 5)
		post_p		0.54 (0.52, 0.7)		0.74 (0.52, 0.88)		0.61 (0.51, 0.74)		0.66 (0.51, 0.86)		0.63 (0.51, 0.7)		0.62 (0.57, 0.85)		0.64 (0.55, 0.87)		0.77 (0.54, 0.84)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.067 (0, 0.183)		0.083 (0.045, 0.16)		0.08 (0, 0.139)		0.106 (0.038, 0.172)		0 (0, 0.16)		0.092 (0, 0.193)		0.027 (0, 0.176)		0.072 (0, 0.095)

Futility:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Hormone_therapies	count	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3
		time	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)	4 (4, 5)
		n	13 (9, 15)	1 (0, 4)	8 (7, 12)	3 (1, 4)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	2 (0, 3)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		post_p	0.46 (0.19, 0.48)	0.39 (0.3, 0.47)	0.44 (0.37, 0.48)	0.46 (0.34, 0.49)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.37 (0.37, 0.37)	0.48 (0.48, 0.48)	0.47 (0.47, 0.47)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.055 (0.053, 0.215)	0.058 (0.012, 0.104)	0.214 (0.139, 0.286)	0.137 (0.027, 0.265)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.118 (0.024, 0.212)	0 (0, 0)	0.492 (0.492, 0.492)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
	Taxel_therapies	count	23	23	23	23	23	23	23	23	23	23	23	23	23	23	23	23
		time	20 (5, 34)	20 (5, 34)	20 (5, 34)	20 (5, 34)	20 (5, 34)	20 (5, 34)	20 (5, 34)	20 (5, 34)	20 (5, 34)	20 (5, 34)	20 (5, 34)	20 (5, 34)	20 (5, 34)	20 (5, 34)	20 (5, 34)	20 (5, 34)
		n	11 (3, 41)	3 (1, 9)	5 (3, 10)	8 (4, 13)	2 (0, 8)	1 (0, 4)	2 (0, 3)	1 (0, 4)	5 (1, 11)	4 (1, 9)	3 (1, 13)	3 (2, 9)	1 (0, 5)	1 (0, 7)	2 (0, 4)	1 (0, 3)
		post_p	0.28 (0.09, 0.44)	0.26 (0.16, 0.43)	0.21 (0.08, 0.45)	0.26 (0.04, 0.46)	0.34 (0.23, 0.45)	0.41 (0.18, 0.48)	0.28 (0.21, 0.42)	0.28 (0.08, 0.45)	0.35 (0.21, 0.41)	0.32 (0.15, 0.48)	0.33 (0.08, 0.46)	0.3 (0.16, 0.46)	0.36 (0.23, 0.47)	0.36 (0.26, 0.5)	0.4 (0.29, 0.49)	0.3 (0.21, 0.43)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.142 (0.113, 0.785)	0.258 (0.127, 0.583)	0.271 (0.161, 0.527)	0.216 (0.163, 0.546)	0.163 (0.12, 0.786)	0.168 (0, 0.288)	0.309 (0.194, 0.683)	0.304 (0.173, 0.77)	0.179 (0.117, 0.47)	0.166 (0.102, 0.436)	0.292 (0.153, 1.058)	0.271 (0.106, 0.678)	0.279 (0.133, 1.477)	0.163 (0.103, 0.406)	0.189 (0.089, 0.98)	0.253 (0.106, 1.298)
	Carboplatin	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
		time	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)
		n	3 (3, 3)	0 (0, 0)	2 (2, 2)	1 (1, 1)	5 (5, 5)	8 (8, 8)	1 (1, 1)	0 (0, 0)	1 (1, 1)	0 (0, 0)	2 (2, 2)	0 (0, 0)	0 (0, 0)	3 (3, 3)	1 (1, 1)	2 (2, 2)
		post_p	0.27 (0.27, 0.27)	NA (NA, NA)	0.39 (0.39, 0.39)	0.27 (0.27, 0.27)	0.16 (0.16, 0.16)	0.45 (0.45, 0.45)	0.25 (0.25, 0.25)	NA (NA, NA)	0.34 (0.34, 0.34)	NA (NA, NA)	0.24 (0.24, 0.24)	NA (NA, NA)	NA (NA, NA)	0.35 (0.35, 0.35)	0.44 (0.44, 0.44)	0.32 (0.32, 0.32)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.322 (0.322, 0.322)	NA (NA, NA)	0.206 (0.206, 0.206)	2.238 (2.238, 2.238)	0.074 (0.074, 0.074)	0.201 (0.201, 0.201)	2.036 (2.036, 2.036)	NA (NA, NA)	1.442 (1.442, 1.442)	NA (NA, NA)	0.2 (0.2, 0.2)	NA (NA, NA)	NA (NA, NA)	0.294 (0.294, 0.294)	0.249 (0.249, 0.249)	0.369 (0.369, 0.369)
TP53- & AR-	Hormone_therapies	count	145	145			145	145
		time	13 (7, 28)	13 (7, 28)			13 (7, 28)	13 (7, 28)
		n	23 (16, 47)	4 (2, 10)			2 (0, 7)	2 (0, 8)
		post_p	0.3 (0.11, 0.45)	0.35 (0.16, 0.48)			0.36 (0.23, 0.49)	0.37 (0.22, 0.48)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.13 (0.105, 0.178)	0.173 (0.102, 0.41)			0.194 (0.087, 0.678)	0.196 (0.107, 0.586)
	Taxel_therapies	count	121	121			121	121
		time	21 (13, 31)	21 (13, 31)			21 (13, 31)	21 (13, 31)
		n	20 (9, 55)	6 (2, 12)			4 (2, 11)	4 (1, 9)
		post_p	0.3 (0.1, 0.46)	0.35 (0.14, 0.48)			0.37 (0.18, 0.48)	0.37 (0.2, 0.48)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.13 (0.109, 0.219)	0.163 (0.097, 0.402)			0.156 (0.101, 0.363)	0.19 (0.107, 0.519)
	Carboplatin	count	109	109			109	109
		time	21 (13, 31)	21 (13, 31)			21 (13, 31)	21 (13, 31)
		n	19 (7, 52)	4 (1, 8)			6 (3, 13)	6 (3, 12)
		post_p	0.32 (0.11, 0.47)	0.36 (0.16, 0.48)			0.34 (0.15, 0.48)	0.36 (0.16, 0.48)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.131 (0.105, 0.18)	0.186 (0.103, 0.541)			0.147 (0.096, 0.349)	0.149 (0.095, 0.361)
	Niraparib	count	131	131			131	131
		time	23 (13, 31)	23 (13, 31)			23 (13, 31)	23 (13, 31)
		n	16 (7, 55)	4 (2, 11)			7 (3, 13)	6 (2, 13)
		post_p	0.3 (0.1, 0.47)	0.36 (0.17, 0.48)			0.34 (0.14, 0.48)	0.34 (0.15, 0.48)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.134 (0.108, 0.205)	0.169 (0.114, 0.554)			0.142 (0.099, 0.349)	0.156 (0.09, 0.409)
TP53+	Hormone_therapies	count			4	4			4	4			4	4			4	4
		time			11 (9, 12)	11 (9, 12)			11 (9, 12)	11 (9, 12)			11 (9, 12)	11 (9, 12)			11 (9, 12)	11 (9, 12)
		n			16 (15, 17)	4 (3, 4)			1 (0, 3)	1 (0, 2)			1 (0, 4)	2 (2, 3)			2 (1, 2)	2 (0, 4)
		post_p			0.36 (0.16, 0.49)	0.3 (0.12, 0.44)			0.5 (0.5, 0.5)	0.35 (0.31, 0.42)			0.44 (0.42, 0.46)	0.4 (0.25, 0.47)			0.32 (0.22, 0.41)	0.27 (0.23, 0.4)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.151 (0.102, 0.179)	0.243 (0.143, 0.379)			0.074 (0.015, 0.133)	0.687 (0.282, 0.838)			0.165 (0.148, 0.182)	0.162 (0.112, 0.307)			0.22 (0.049, 1.008)	0.819 (0.247, 4.35)
	Taxel_therapies	count			366	366			366	366			366	366			366	366
		time			20 (11, 32)	20 (11, 32)			20 (11, 32)	20 (11, 32)			20 (11, 32)	20 (11, 32)			20 (11, 32)	20 (11, 32)
		n			7 (4, 14)	8 (5, 15)			2 (0, 5)	2 (0, 5)			4 (2, 8)	4 (2, 8)			2 (0, 5)	2 (0, 5)
		post_p			0.2 (0.07, 0.41)	0.17 (0.04, 0.42)			0.34 (0.2, 0.47)	0.35 (0.2, 0.47)			0.29 (0.11, 0.45)	0.28 (0.13, 0.47)			0.35 (0.19, 0.47)	0.34 (0.21, 0.47)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.246 (0.16, 0.45)	0.249 (0.162, 0.49)			0.292 (0.139, 0.991)	0.272 (0.137, 1.198)			0.268 (0.152, 0.723)	0.255 (0.141, 0.729)			0.28 (0.142, 1.205)	0.287 (0.143, 1.245)
	Carboplatin	count			3	3			3	3			3	3			3	3
		time			17 (15, 28)	17 (15, 28)			17 (15, 28)	17 (15, 28)			17 (15, 28)	17 (15, 28)			17 (15, 28)	17 (15, 28)
		n			7 (6, 8)	9 (6, 18)			2 (1, 3)	5 (3, 5)			5 (1, 6)	3 (1, 4)			1 (1, 2)	4 (2, 7)
		post_p			0.41 (0.37, 0.42)	0.45 (0.31, 0.46)			0.44 (0.37, 0.46)	0.45 (0.32, 0.48)			0.37 (0.33, 0.4)	0.42 (0.37, 0.43)			0.35 (0.29, 0.36)	0.37 (0.32, 0.43)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.158 (0.147, 0.17)	0.18 (0.147, 0.252)			0.137 (0.089, 0.476)	0.197 (0.101, 0.383)			0.129 (0.121, 0.137)	0.2 (0.159, 0.242)			0.493 (0.296, 0.655)	0.201 (0.197, 0.847)
	Niraparib	count			1	1			1	1			1	1			1	1
		time			20 (20, 20)	20 (20, 20)			20 (20, 20)	20 (20, 20)			20 (20, 20)	20 (20, 20)			20 (20, 20)	20 (20, 20)
		n			6 (6, 6)	7 (7, 7)			6 (6, 6)	4 (4, 4)			3 (3, 3)	2 (2, 2)			2 (2, 2)	2 (2, 2)
		post_p			0.24 (0.24, 0.24)	0.44 (0.44, 0.44)			0.44 (0.44, 0.44)	0.36 (0.36, 0.36)			0.49 (0.49, 0.49)	0.25 (0.25, 0.25)			0.26 (0.26, 0.26)	0.41 (0.41, 0.41)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.176 (0.176, 0.176)	0.188 (0.188, 0.188)			0.11 (0.11, 0.11)	0.202 (0.202, 0.202)			0.136 (0.136, 0.136)	0.291 (0.291, 0.291)			0.348 (0.348, 0.348)	0.19 (0.19, 0.19)
DRD+	Hormone_therapies	count					9	9	9	9					9	9	9	9
		time					30 (23, 34)	30 (23, 34)	30 (23, 34)	30 (23, 34)					30 (23, 34)	30 (23, 34)	30 (23, 34)	30 (23, 34)
		n					2 (0, 5)	4 (0, 10)	6 (2, 14)	3 (2, 6)					4 (1, 6)	5 (3, 8)	3 (2, 10)	3 (1, 6)
		post_p					0.36 (0.1, 0.41)	0.37 (0.31, 0.46)	0.42 (0.18, 0.47)	0.42 (0.29, 0.48)					0.42 (0.27, 0.45)	0.41 (0.24, 0.48)	0.36 (0.33, 0.43)	0.35 (0.19, 0.47)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.237 (0.157, 0.553)	0.146 (0.132, 0.306)	0.156 (0.105, 0.316)	0.2 (0.144, 0.29)					0.153 (0.096, 0.51)	0.162 (0.115, 0.266)	0.163 (0.138, 0.286)	0.219 (0.136, 0.302)
	Taxel_therapies	count					60	60	60	60					60	60	60	60
		time					29 (22, 34)	29 (22, 34)	29 (22, 34)	29 (22, 34)					29 (22, 34)	29 (22, 34)	29 (22, 34)	29 (22, 34)
		n					5 (2, 13)	5 (2, 11)	2 (1, 6)	2 (1, 5)					4 (1, 7)	4 (1, 8)	2 (1, 5)	2 (0, 5)
		post_p					0.34 (0.16, 0.45)	0.35 (0.13, 0.47)	0.34 (0.21, 0.43)	0.32 (0.15, 0.43)					0.36 (0.19, 0.48)	0.36 (0.22, 0.48)	0.35 (0.21, 0.46)	0.34 (0.21, 0.46)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.158 (0.113, 0.413)	0.159 (0.104, 0.348)	0.294 (0.163, 0.786)	0.294 (0.168, 0.885)					0.165 (0.106, 0.573)	0.178 (0.112, 0.664)	0.265 (0.15, 1.697)	0.306 (0.169, 1.229)
	Carboplatin	count					10	10	10	10					10	10	10	10
		time					16 (8, 28)	16 (8, 28)	16 (8, 28)	16 (8, 28)					16 (8, 28)	16 (8, 28)	16 (8, 28)	16 (8, 28)
		n					6 (3, 12)	4 (2, 8)	4 (2, 4)	4 (3, 7)					3 (2, 9)	4 (2, 6)	2 (1, 5)	3 (1, 6)
		post_p					0.29 (0.17, 0.46)	0.44 (0.36, 0.48)	0.42 (0.2, 0.5)	0.34 (0.23, 0.46)					0.4 (0.18, 0.47)	0.36 (0.14, 0.44)	0.33 (0.28, 0.41)	0.39 (0.24, 0.46)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.17 (0.107, 0.299)	0.149 (0.131, 0.238)	0.208 (0.121, 0.441)	0.202 (0.112, 0.326)					0.167 (0.092, 0.444)	0.219 (0.045, 0.378)	0.584 (0.114, 0.839)	0.191 (0.144, 2.067)
	Niraparib	count					5	5	5	5					5	5	5	5
		time					21 (17, 28)	21 (17, 28)	21 (17, 28)	21 (17, 28)					21 (17, 28)	21 (17, 28)	21 (17, 28)	21 (17, 28)
		n					2 (1, 11)	6 (5, 16)	3 (1, 5)	4 (3, 6)					3 (2, 5)	4 (3, 15)	3 (2, 7)	1 (1, 4)
		post_p					0.32 (0.12, 0.35)	0.32 (0.18, 0.44)	0.33 (0.17, 0.42)	0.38 (0.14, 0.46)					0.29 (0.21, 0.35)	0.43 (0.24, 0.44)	0.48 (0.28, 0.49)	0.37 (0.28, 0.42)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.294 (0.17, 0.973)	0.122 (0.097, 0.198)	0.238 (0.147, 0.458)	0.249 (0.125, 0.365)					0.211 (0.154, 0.278)	0.139 (0.131, 0.273)	0.196 (0.123, 0.642)	0.335 (0.21, 0.895)
TEfus+	Hormone_therapies	count		3		3		3		3		3		3		3		3
		time		26 (14, 29)		26 (14, 29)		26 (14, 29)		26 (14, 29)		26 (14, 29)		26 (14, 29)		26 (14, 29)		26 (14, 29)
		n		4 (2, 7)		11 (5, 13)		4 (1, 9)		3 (1, 3)		4 (3, 5)		4 (3, 6)		3 (1, 4)		3 (1, 7)
		post_p		0.33 (0.29, 0.37)		0.41 (0.28, 0.46)		0.46 (0.45, 0.46)		0.34 (0.23, 0.46)		0.33 (0.29, 0.39)		0.41 (0.38, 0.43)		0.32 (0.27, 0.44)		0.45 (0.29, 0.47)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.222 (0.181, 0.477)		0.142 (0.136, 0.166)		0.127 (0.112, 0.142)		0.377 (0.171, 0.776)		0.128 (0.104, 0.211)		0.135 (0.124, 0.184)		0.239 (0.15, 0.341)		0.24 (0.119, 0.703)
	Taxel_therapies	count		106		106		106		106		106		106		106		106
		time		21 (12, 32)		21 (12, 32)		21 (12, 32)		21 (12, 32)		21 (12, 32)		21 (12, 32)		21 (12, 32)		21 (12, 32)
		n		5 (2, 13)		8 (5, 14)		4 (1, 9)		2 (0, 4)		5 (2, 10)		4 (2, 6)		2 (0, 6)		2 (0, 4)
		post_p		0.35 (0.14, 0.48)		0.18 (0.03, 0.42)		0.37 (0.2, 0.48)		0.36 (0.2, 0.45)		0.36 (0.18, 0.48)		0.3 (0.14, 0.45)		0.37 (0.21, 0.48)		0.34 (0.21, 0.45)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0.165 (0.098, 0.35)		0.233 (0.168, 0.477)		0.167 (0.102, 0.42)		0.304 (0.165, 1.175)		0.157 (0.092, 0.369)		0.233 (0.146, 0.686)		0.217 (0.105, 0.789)		0.293 (0.161, 1.123)
	Carboplatin	count		8		8		8		8		8		8		8		8
		time		21 (15, 32)		21 (15, 32)		21 (15, 32)		21 (15, 32)		21 (15, 32)		21 (15, 32)		21 (15, 32)		21 (15, 32)
		n		3 (1, 5)		6 (3, 16)		4 (3, 9)		3 (1, 4)		4 (3, 11)		3 (2, 6)		4 (3, 6)		3 (1, 6)
		post_p		0.23 (0.19, 0.36)		0.38 (0.25, 0.49)		0.44 (0.21, 0.49)		0.32 (0.21, 0.44)		0.39 (0.33, 0.47)		0.41 (0.29, 0.47)		0.35 (0.2, 0.46)		0.36 (0.3, 0.44)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.252 (0.162, 1.371)		0.163 (0.119, 0.338)		0.125 (0.082, 0.206)		0.249 (0.183, 0.474)		0.122 (0.098, 0.336)		0.2 (0.149, 0.489)		0.147 (0.127, 0.341)		0.196 (0.132, 0.929)
	Niraparib	count		5		5		5		5		5		5		5		5
		time		26 (18, 32)		26 (18, 32)		26 (18, 32)		26 (18, 32)		26 (18, 32)		26 (18, 32)		26 (18, 32)		26 (18, 32)
		n		3 (2, 4)		6 (3, 22)		4 (3, 10)		2 (0, 12)		4 (3, 10)		6 (1, 11)		3 (1, 5)		3 (1, 13)
		post_p		0.38 (0.29, 0.43)		0.28 (0.21, 0.38)		0.39 (0.24, 0.44)		0.36 (0.31, 0.41)		0.35 (0.17, 0.38)		0.4 (0.4, 0.42)		0.4 (0.24, 0.49)		0.33 (0.21, 0.45)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.19 (0.122, 0.457)		0.228 (0.151, 0.42)		0.13 (0.128, 0.213)		0.377 (0.152, 0.845)		0.137 (0.111, 0.35)		0.152 (0.124, 0.195)		0.135 (0.122, 0.569)		0.251 (0.157, 0.355)